target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id TRPC7,492,Q9HCX4,Human,amiloride,2421,,16231,NC(=NC(=O)c1nc(Cl)c(nc1N)N)N,"InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15)",XSDQTOBWRPYKKA-UHFFFAOYSA-N,Channel blocker,None,,,,,,,,,,,,,=,,,,, TRPC7,492,Q9HCX4,Human,2-APB,2433,,1598,NCCOB(c1ccccc1)c1ccccc1,"InChI=1S/C14H16BNO/c16-11-12-17-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10H,11-12,16H2",BLZVCIGGICSWIG-UHFFFAOYSA-N,Channel blocker,None,,,,,,,,,,,,,=,,,,, TRPC7,492,Q9WVC5,Mouse,La3+,2434,,104897,,,,Channel blocker,Antagonist,,,,100,,,,,,,,,=,,,,10488066, TRPC7,492,Q9WVC5,Mouse,DOG,2435,,148879,CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC)CO,"InChI=1S/C19H36O5/c1-3-5-7-9-11-13-18(21)23-16-17(15-20)24-19(22)14-12-10-8-6-4-2/h17,20H,3-16H2,1-2H3/t17-/m0/s1",ZQBULZYTDGUSSK-KRWDZBQOSA-N,Activator,Agonist,,,,100,,,,,,,,,,,,,10488066, TRPC7,492,Q9WVC5,Mouse,OAG,2436,,5353264,CCCCCCCC/C=C/CCCCCCCC(=O)OCC(OC(=O)C)CO,"InChI=1S/C23H42O5/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)27-20-22(19-24)28-21(2)25/h10-11,22,24H,3-9,12-20H2,1-2H3/b11-10+",PWTCCMJTPHCGMS-ZHACJKMWSA-N,Activator,Agonist,,,,100,,,,,,,,,,,,,10488066, TRPC7,492,Q9WVC5,Mouse,SKF96365,2441,,104956,COc1ccc(cc1)CCCOC(c1ccc(cc1)OC)Cn1ccnc1,"InChI=1S/C22H26N2O3/c1-25-20-9-5-18(6-10-20)4-3-15-27-22(16-24-14-13-23-17-24)19-7-11-21(26-2)12-8-19/h5-14,17,22H,3-4,15-16H2,1-2H3",HLMBXBGDBBCYII-UHFFFAOYSA-N,Channel blocker,Antagonist,,,,25,,,,,,,,,=,,,,10488066, TRPC7,492,Q9HCX4,Human,SH045,9968,,134611888,CNC(=O)O[C@H]1CC(=C)[C@@H]([C@@]2([C@@H]1C(C)(C)CCC2)C)CC[C@@](C=C)(O)C,"InChI=1S/C22H37NO3/c1-8-21(5,25)13-10-16-15(2)14-17(26-19(24)23-7)18-20(3,4)11-9-12-22(16,18)6/h8,16-18,25H,1-2,9-14H2,3-7H3,(H,23,24)/t16-,17-,18-,21+,22+/m0/s1",VDWLBNKHHJKPOQ-LDAQOBCYSA-N,Channel blocker,None,,,,,pIC50,,7.7,,IC50,,20.0,,~,,,,29522264, TRPC7,492,Q9HCX4,Human,SH045,9968,,134611888,CNC(=O)O[C@H]1CC(=C)[C@@H]([C@@]2([C@@H]1C(C)(C)CCC2)C)CC[C@@](C=C)(O)C,"InChI=1S/C22H37NO3/c1-8-21(5,25)13-10-16-15(2)14-17(26-19(24)23-7)18-20(3,4)11-9-12-22(16,18)6/h8,16-18,25H,1-2,9-14H2,3-7H3,(H,23,24)/t16-,17-,18-,21+,22+/m0/s1",VDWLBNKHHJKPOQ-LDAQOBCYSA-N,Channel blocker,None,,,,,pIC50,,6.66,,IC50,,220.0,,=,"Measuring inhibition of calcium flux in HEK293 cells expressing hTRPC7, in a FLIPR assay.",,,29522264, TRPC7,492,Q9HCX4,Human,pyrazolopyrimidine 4n,10281,,121279842,CCOC(=O)N1CCC(CC1)c1cc(O)n2c(n1)c(c1ccc(cc1)C(F)(F)F)c(n2)C,"InChI=1S/C22H23F3N4O3/c1-3-32-21(31)28-10-8-14(9-11-28)17-12-18(30)29-20(26-17)19(13(2)27-29)15-4-6-16(7-5-15)22(23,24)25/h4-7,12,14,30H,3,8-11H2,1-2H3",JCCIFATWQJZIDU-UHFFFAOYSA-N,Activator,Activation,,,,,pIC50,,6.05,,IC50,,890.0,,=,,,,28395140, TRPC7,492,Q9HCX4,Human,SAR7334,10283,,53378752,N#Cc1ccc(c(c1)Cl)O[C@H]1[C@@H](Cc2c1cccc2)N1CCC[C@H](C1)N,"InChI=1S/C21H22ClN3O/c22-18-10-14(12-23)7-8-20(18)26-21-17-6-2-1-4-15(17)11-19(21)25-9-3-5-16(24)13-25/h1-2,4,6-8,10,16,19,21H,3,5,9,11,13,24H2/t16-,19-,21-/m1/s1",RLKRLNQEXBPQGQ-OZOXKJRCSA-N,Channel blocker,None,,,,,pIC50,,6.65,,IC50,,226.0,,=,,,,25847402, TRPC7,492,Q9HCX4,Human,larixyl acetate,10295,,91746934,C=CC(OC(=O)C)(CCC1C(=C)CC(C2C1(C)CCCC2(C)C)OC(=O)C)C,"InChI=1S/C24H38O4/c1-9-23(7,28-18(4)26)14-11-19-16(2)15-20(27-17(3)25)21-22(5,6)12-10-13-24(19,21)8/h9,19-21H,1-2,10-15H2,3-8H3",CFEOXVWJRPHLSF-UHFFFAOYSA-N,Channel blocker,Inhibition,,,,,pIC50,,6.3,,IC50,,500.0,,~,,,,26500253, TRPC7,492,Q9HCX4,Human,OptoBI-1,12525,,146018968,CCCCC1=CC=C(C=C1)N=NC2=CC=C(C=C2)CCCC(=O)N3CCC(CC3)N4C5=CC=CC=C5NC4=O,"InChI=1S/C32H37N5O2/c1-2-3-7-24-12-16-26(17-13-24)34-35-27-18-14-25(15-19-27)8-6-11-31(38)36-22-20-28(21-23-36)37-30-10-5-4-9-29(30)33-32(37)39/h4-5,9-10,12-19,28H,2-3,6-8,11,20-23H2,1H3,(H,33,39)",LUASQYYRQCWOMA-UHFFFAOYSA-N,Activator,Activation,photoswitch activation; concentration range: 1-2x10-5M,,,,,,,,,,,,=,,,,30997005, TRPC7,492,Q9HCX4,Human,BI 749327,12530,,138377580,NC1=CC=C(N=N1)C2CCN(CC2)C(=O)C3=CC=C(OC4=CC=C(C=C4)C(F)(F)F)C=C3,"InChI=1S/C23H21F3N4O2/c24-23(25,26)17-3-7-19(8-4-17)32-18-5-1-16(2-6-18)22(31)30-13-11-15(12-14-30)20-9-10-21(27)29-28-20/h1-10,15H,11-14H2,(H2,27,29)",RGYMFGHHIDRCBN-UHFFFAOYSA-N,Channel blocker,Antagonist,,,,,pIC50,,6.3,,,,,,=,,,,31028142,