target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id
TRPM5,497,Q9JJH7,Mouse,Ca2+,707,,,,,,Activator,Agonist,,yes,,,pEC50,6.2,,4.5,EC50,30000.0,,700.0,=,,,intracellular,15670874|12842017|14657398,
TRPM5,497,Q9NZQ8,Human,spermine,710,,1103,NCCCNCCCCNCCCN,"InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2",PFNFFQXMRSDOHW-UHFFFAOYSA-N,Channel blocker,None,,,,,pIC50,,4.43,,IC50,,37000.0,,=,,,intracellular,,
TRPM5,497,Q9NZQ8,Human,H+,2346,,1038,,,,Channel blocker,None,,,,,pIC50,,3.2,,IC50,,630000.0,,=,,,Extracellular,,
TRPM5,497,Q9NZQ8,Human,flufenamic acid,2447,,3371,OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F,"InChI=1S/C14H10F3NO2/c15-14(16,17)9-4-3-5-10(8-9)18-12-7-2-1-6-11(12)13(19)20/h1-8,18H,(H,19,20)",LPEPZBJOKDYZAD-UHFFFAOYSA-N,Channel blocker,None,,,,,pIC50,,4.62,,IC50,,24000.0,,=,,,,,
TRPM5,497,Q9NZQ8,Human,compound 39 [PMID: 36402081],12537,,167993652,ClC=1C=C(C=C(C1)F)[C@H]2N[C@H](CC3=CC(=CC=C23)C#N)CO,"InChI=1S/C17H14ClFN2O/c18-13-4-12(5-14(19)7-13)17-16-2-1-10(8-20)3-11(16)6-15(9-22)21-17/h1-5,7,15,17,21-22H,6,9H2/t15-,17-/m1/s1",UOCQJHUNCIRIPU-NVXWUHKLSA-N,Activator,Agonist,,,,,pEC50,,7.5,,,,,,=,Detection method FLIPR FMP dye assay.,,,36402081,
TRPM5,497,Q9NZQ8,Human,APV206690A,12538,,21304318,COC1=C(OCSC2=NC3=C(N2)C=CC=C3)C=CC=C1,"InChI=1S/C15H14N2O2S/c1-18-13-8-4-5-9-14(13)19-10-20-15-16-11-6-2-3-7-12(11)17-15/h2-9H,10H2,1H3,(H,16,17)",VWPMKWIMDYQBLH-UHFFFAOYSA-N,Allosteric modulator,Potentiation,,,,,pEC50,,4.04,,EC50,,92200.0,,=,"Determined via whole cell patch clamp experiments, with free [Ca2+]i at 1 μM",,,35058176,
TRPM5,497,Q9NZQ8,Human,APV207010A,12539,,2767151,[N+](=O)([O-])C=1C=CC(=NC1)OC2=C(SC=C2)C(=O)OC,"InChI=1S/C11H8N2O5S/c1-17-11(14)10-8(4-5-19-10)18-9-3-2-7(6-12-9)13(15)16/h2-6H,1H3",GSBNWRFUGOOOEO-UHFFFAOYSA-N,Allosteric modulator,Potentiation,,,,,pEC50,,4.42,,EC50,,38400.0,,=,"Determined via whole cell patch clamp experiments, with free [Ca2+]i at 1 μM",,,35058176,
TRPM5,497,Q9NZQ8,Human,APV207094A,12540,,682464,CCOC(=O)C/N=C/1\SC2=C(C=CC=C2)N1C,"InChI=1S/C12H14N2O2S/c1-3-16-11(15)8-13-12-14(2)9-6-4-5-7-10(9)17-12/h4-7H,3,8H2,1-2H3/b13-12-",WYEBSLMBMXIUQI-SEYXRHQNSA-N,Allosteric modulator,Potentiation,,,,,pEC50,,4.43,,EC50,,37100.0,,=,"Determined via whole cell patch clamp experiments, with free [Ca2+]i at 1 μM",,,35058176,
TRPM5,497,Q9NZQ8,Human,APV207095A,12541,,1870934,CN1/C(/SC2=C1C=CC=C2)=N/C(=S)NCC=C,"InChI=1S/C12H13N3S2/c1-3-8-13-11(16)14-12-15(2)9-6-4-5-7-10(9)17-12/h3-7H,1,8H2,2H3,(H,13,16)/b14-12-",XCGANXSUHYMPGJ-OWBHPGMISA-N,Allosteric modulator,Potentiation,,,,,pEC50,,5.03,,EC50,,9400.0,,=,"Determined via whole cell patch clamp experiments, with free [Ca2+]i at 1 μM",,,35058176,