target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id Kv1.7,544,Q17ST2,Mouse,diltiazem,2298,,39186,COc1ccc(cc1)[C@@H]1Sc2ccccc2N(C(=O)[C@@H]1OC(=O)C)CCN(C)C,"InChI=1S/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3/t20-,21+/m1/s1",HSUGRBWQSSZJOP-RTWAWAEBSA-N,Channel blocker,None,,,,,pIC50,,4.2,,,,,,,,,,9488722, Kv1.7,544,Q96RP8,Human,quinidine,2342,,441074,C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@H](c1ccnc2c1cc(OC)cc2)O,"InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19+,20-/m0/s1",LOUPRKONTZGTKE-LHHVKLHASA-N,Channel blocker,None,,,,,pKd,,4.8,,,,,,,,,,11896454, Kv1.7,544,Q17ST2,Mouse,tetraethylammonium,2343,,5413,CC[N+](CC)(CC)CC,"InChI=1S/C8H20N/c1-5-9(6-2,7-3)8-4/h5-8H2,1-4H3/q+1",CBXCPBUEXACCNR-UHFFFAOYSA-N,Channel blocker,None,,,,,pIC50,,1.1,,,,,,,,,,9488722, Kv1.7,544,Q96RP8,Human,tetraethylammonium,2343,,5413,CC[N+](CC)(CC)CC,"InChI=1S/C8H20N/c1-5-9(6-2,7-3)8-4/h5-8H2,1-4H3/q+1",CBXCPBUEXACCNR-UHFFFAOYSA-N,Channel blocker,None,,,,,pKd,,4.1,,,,,,,,,,11896454, Kv1.7,544,Q96RP8,Human,verapamil,2406,,2520,COc1ccc(cc1OC)CCN(CCCC(c1ccc(c(c1)OC)OC)(C(C)C)C#N)C,"InChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3",SGTNSNPWRIOYBX-UHFFFAOYSA-N,Channel blocker,None,,,,,pKd,,4.8,,,,,,,,,,11896454, Kv1.7,544,Q17ST2,Mouse,cromakalim,2413,,443423,N#Cc1ccc2c(c1)C(N1CCCC1=O)C(C(O2)(C)C)O,"InChI=1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3",TVZCRIROJQEVOT-UHFFFAOYSA-N,Channel blocker,None,,,,,pIC50,,3.3,,,,,,,,,,9488722, Kv1.7,544,Q17ST2,Mouse,fampridine,2416,,1727,Nc1ccncc1,"InChI=1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7)",NUKYPUAOHBNCPY-UHFFFAOYSA-N,Channel blocker,None,,,,,pIC50,,3.6,,IC50,,245000.0,,=,,,,9488722, Kv1.7,544,Q17ST2,Mouse,fampridine,2416,,1727,Nc1ccncc1,"InChI=1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7)",NUKYPUAOHBNCPY-UHFFFAOYSA-N,Channel blocker,Pore blocker,,,,,pKd,,3.8,,,,,,=,,,,16801386, Kv1.7,544,Q17ST2,Mouse,capsaicin,2486,,1548943,COc1cc(CNC(=O)CCCC/C=C/C(C)C)ccc1O,"InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+",YKPUWZUDDOIDPM-SOFGYWHQSA-N,Channel blocker,None,,,,,pIC50,,4.6,,,,,,,,,,9488722, Kv1.7,544,Q17ST2,Mouse,resiniferatoxin,2491,,5702546,COc1cc(ccc1O)CC(=O)OCC1=C[C@H]2[C@H]3O[C@]4(O[C@]2([C@H]2[C@@](C1)(O)C(=O)C(=C2)C)[C@@H](C[C@@]3(O4)C(=C)C)C)Cc1ccccc1,"InChI=1S/C37H40O9/c1-21(2)35-17-23(4)37-27(33(35)44-36(45-35,46-37)19-24-9-7-6-8-10-24)14-26(18-34(41)30(37)13-22(3)32(34)40)20-43-31(39)16-25-11-12-28(38)29(15-25)42-5/h6-15,23,27,30,33,38,41H,1,16-20H2,2-5H3/t23-,27+,30-,33-,34-,35-,36-,37-/m1/s1",DSDNAKHZNJAGHN-MXTYGGKSSA-N,Channel blocker,None,,,,,pIC50,,4.7,,,,,,,,,,9488722, Kv1.7,544,Q17ST2,Mouse,nifedipine,2514,,4485,COC(=O)C1=C(C)NC(=C(C1c1ccccc1[N+](=O)[O-])C(=O)OC)C,"InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3",HYIMSNHJOBLJNT-UHFFFAOYSA-N,Channel blocker,None,,,,,pIC50,,4.9,,,,,,,,,,9488722, Kv1.7,544,Q17ST2,Mouse,margatoxin,2547,,,,,,Channel blocker,None,,,,,pIC50,,6.9,,,,,,,,,,9488722, Kv1.7,544,Q17ST2,Mouse,ShK Toxin,2549,,,,,,Channel blocker,None,,,,,pIC50,,7.9,,,,,,,,,,9488722, Kv1.7,544,Q17ST2,Mouse,noxiustoxin,2552,,,,,,Channel blocker,None,,,,,pIC50,,7.7,,,,,,=,,,,9488722, Kv1.7,544,Q17ST2,Mouse,CP-339818,2558,,656767,CCCCCN=c1ccn(c2c1cccc2)Cc1ccccc1,"InChI=1S/C21H24N2/c1-2-3-9-15-22-20-14-16-23(17-18-10-5-4-6-11-18)21-13-8-7-12-19(20)21/h4-8,10-14,16H,2-3,9,15,17H2,1H3",MMGAVKCAGQCFHS-UHFFFAOYSA-N,Channel blocker,None,,,,,pIC50,,5.0,,,,,,,,,,9488722, Kv1.7,544,Q96RP8,Human,flecainide,2560,,3356,O=C(c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F)NCC1CCCCN1,"InChI=1S/C17H20F6N2O3/c18-16(19,20)9-27-12-4-5-14(28-10-17(21,22)23)13(7-12)15(26)25-8-11-3-1-2-6-24-11/h4-5,7,11,24H,1-3,6,8-10H2,(H,25,26)",DJBNUMBKLMJRSA-UHFFFAOYSA-N,Channel blocker,None,,,,,pKd,,5.1,,,,,,,,,,11896454, Kv1.7,544,Q96RP8,Human,amiodarone,2566,,2157,CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2,"InChI=1S/C25H29I2NO3/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3",IYIKLHRQXLHMJQ-UHFFFAOYSA-N,Channel blocker,None,,,,,pKd,,4.5,,,,,,,,,,11896454, Kv1.7,544,Q17ST2,Mouse,tedisamil,2567,,65825,C1CCC2(C1)C1CN(CC2CN(C1)CC1CC1)CC1CC1,"InChI=1S/C19H32N2/c1-2-8-19(7-1)17-11-20(9-15-3-4-15)12-18(19)14-21(13-17)10-16-5-6-16/h15-18H,1-14H2",CTIRHWCPXYGDGF-UHFFFAOYSA-N,Channel blocker,None,,,,,pIC50,,4.7,,,,,,,,,,9488722, Kv1.7,544,Q17ST2,Mouse,conkunitzin-S1 toxin,7758,,,,,,Channel blocker,Pore blocker,,,,,pIC50,,6.4,,IC50,,439.0,,=,,,,22438204,