target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id Retinoic acid receptor-α,590,P10276,Human,AGN193109,2640,,177238,Cc1ccc(cc1)C1=CCC(c2c1cc(cc2)C#Cc1ccc(cc1)C(=O)O)(C)C,"InChI=1S/C28H24O2/c1-19-4-11-22(12-5-19)24-16-17-28(2,3)26-15-10-21(18-25(24)26)7-6-20-8-13-23(14-9-20)27(29)30/h4-5,8-16,18H,17H2,1-3H3,(H,29,30)",NCEQLLNVRRTCKJ-UHFFFAOYSA-N,Antagonist,Inverse agonist,,,,,pIC50,,8.7,,,,,,,,,,8798442|10777502|10637371, Retinoic acid receptor-α,590,P10276,Human,BMS493,2641,,9909190,OC(=O)c1ccc(cc1)/C=C/c1ccc2c(c1)C(=CCC2(C)C)C#Cc1ccccc1,"InChI=1S/C29H24O2/c1-29(2)19-18-24(14-10-21-6-4-3-5-7-21)26-20-23(13-17-27(26)29)9-8-22-11-15-25(16-12-22)28(30)31/h3-9,11-13,15-18,20H,19H2,1-2H3,(H,30,31)/b9-8+",YCADIXLLWMXYKW-CMDGGOBGSA-N,Antagonist,Inverse agonist,,,,,pIC50,,8.4,,,,,,,,,,11805839, Retinoic acid receptor-α,590,P10276,Human,Ro 41-5253,2642,,5312120,CCCCCCCOc1cc2c(cc1/C(=C/c1ccc(cc1)C(=O)O)/C)C(C)(C)CCS2(=O)=O,"InChI=1S/C28H36O5S/c1-5-6-7-8-9-15-33-25-19-26-24(28(3,4)14-16-34(26,31)32)18-23(25)20(2)17-21-10-12-22(13-11-21)27(29)30/h10-13,17-19H,5-9,14-16H2,1-4H3,(H,29,30)/b20-17+",JEIWQRITHXYGIF-LVZFUZTISA-N,Antagonist,Antagonist,,,,,pIC50,7.22,,6.34,,,,,=,,,,8264595|1323127, Retinoic acid receptor-α,590,P10276,Human,BMS614,2643,,445091,O=C(c1ccc2c(c1)C(=CCC2(C)C)c1cnc2c(c1)cccc2)Nc1ccc(cc1)C(=O)O,"InChI=1S/C29H24N2O3/c1-29(2)14-13-23(21-15-19-5-3-4-6-26(19)30-17-21)24-16-20(9-12-25(24)29)27(32)31-22-10-7-18(8-11-22)28(33)34/h3-13,15-17H,14H2,1-2H3,(H,31,32)(H,33,34)",WGLMBRZXZDAQHP-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pIC50,,8.7,,,,,,,,,,10882070|10421757|11805839, Retinoic acid receptor-α,590,P10276,Human,tretinoin,2644,,444795,C/C(=C\C=C\C(=C\C(=O)O)\C)/C=C/C1=C(C)CCCC1(C)C,"InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+",SHGAZHPCJJPHSC-YCNIQYBTSA-N,Agonist,Agonist,,,yes,,pEC50,,7.77,,EC50,,17.0,,=,,,,19058965, Retinoic acid receptor-α,590,P10276,Human,tretinoin,2644,,444795,C/C(=C\C=C\C(=C\C(=O)O)\C)/C=C/C1=C(C)CCCC1(C)C,"InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+",SHGAZHPCJJPHSC-YCNIQYBTSA-N,Agonist,Agonist,,yes,yes,,pKd,,9.4,,,,,,=,,,,8380496|8264595|10964567|7791761|10637371, Retinoic acid receptor-α,590,P10276,Human,alitretinoin,2645,,449171,C/C(=C/C=C/C(=C/C(=O)O)/C)/C=C/C1=C(C)CCCC1(C)C,"InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+",SHGAZHPCJJPHSC-ZVCIMWCZSA-N,Agonist,Agonist,,,yes,,pKd,,9.5,,,,,,=,,,,3184125|7791761, Retinoic acid receptor-α,590,P10276,Human,TTNPB,2646,,5289501,C/C(=C\c1ccc(cc1)C(=O)O)/c1ccc2c(c1)C(C)(C)CCC2(C)C,"InChI=1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+",FOIVPCKZDPCJJY-JQIJEIRASA-N,Agonist,Agonist,,,,,pIC50,,7.44,,,,,,,,,,8264595|10964567|7791761|10637371, Retinoic acid receptor-α,590,P10276,Human,Ro 40-6055,2647,,2126,O=C(c1ccc2c(c1)C(C)(C)CCC2(C)C)Nc1ccc(cc1)C(=O)O,"InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)",SZWKGOZKRMMLAJ-UHFFFAOYSA-N,Agonist,Agonist,,,,,pEC50,,9.52,,EC50,,0.3,,=,,,,19058965, Retinoic acid receptor-α,590,P10276,Human,Ro 40-6055,2647,,2126,O=C(c1ccc2c(c1)C(C)(C)CCC2(C)C)Nc1ccc(cc1)C(=O)O,"InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)",SZWKGOZKRMMLAJ-UHFFFAOYSA-N,Agonist,Agonist,,,,,pKd,,,,Kd,,6.0,,=,,,,1656191, Retinoic acid receptor-α,590,P10276,Human,tamibarotene,2648,,108143,O=C(c1ccc(cc1)C(=O)O)Nc1ccc2c(c1)C(C)(C)CCC2(C)C,"InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-16(9-10-17(18)21)23-19(24)14-5-7-15(8-6-14)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)",MUTNCGKQJGXKEM-UHFFFAOYSA-N,Agonist,Agonist,,,yes,,pEC50,,7.35,,EC50,,45.0,,=,,,,20925433, Retinoic acid receptor-α,590,P10276,Human,tamibarotene,2648,,108143,O=C(c1ccc(cc1)C(=O)O)Nc1ccc2c(c1)C(C)(C)CCC2(C)C,"InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-16(9-10-17(18)21)23-19(24)14-5-7-15(8-6-14)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)",MUTNCGKQJGXKEM-UHFFFAOYSA-N,Agonist,Agonist,,,yes,,pIC50,,6.9,,,,,,=,,,,3184125|7791761|10637371, Retinoic acid receptor-α,590,P10276,Human,AGN193836,2649,,23001780,O=C(c1cc(F)c(c(c1)F)C(=O)O)Nc1cc2c(c(c1O)Br)C(C)(C)CCC2(C)C,"InChI=1S/C22H22BrF2NO4/c1-21(2)5-6-22(3,4)16-11(21)9-14(18(27)17(16)23)26-19(28)10-7-12(24)15(20(29)30)13(25)8-10/h7-9,27H,5-6H2,1-4H3,(H,26,28)(H,29,30)",FADQHUSDAKOWFT-UHFFFAOYSA-N,Agonist,Agonist,,,,,pKd,,8.4,,,,,,,,,,12372520, Retinoic acid receptor-α,590,P10276,Human,BMS753,2650,,9884820,O=C(c1ccc2c(c1)C(C)(C)C(=O)C2(C)C)Nc1ccc(cc1)C(=O)O,"InChI=1S/C21H21NO4/c1-20(2)15-10-7-13(11-16(15)21(3,4)19(20)26)17(23)22-14-8-5-12(6-9-14)18(24)25/h5-11H,1-4H3,(H,22,23)(H,24,25)",KFBPBWUZXBYJDG-UHFFFAOYSA-N,Agonist,Agonist,,,,,pKi,,8.7,,,,,,=,,,,10421757, Retinoic acid receptor-α,590,P10276,Human,CD666,2652,,10090192,OC(c1ccc2c(c1)C(C)(C)CCC2(C)C)/C=C/c1ccc(cc1)C(=O)O,"InChI=1S/C24H28O3/c1-23(2)13-14-24(3,4)20-15-18(10-11-19(20)23)21(25)12-7-16-5-8-17(9-6-16)22(26)27/h5-12,15,21,25H,13-14H2,1-4H3,(H,26,27)/b12-7+",QCSYBKHFYYISTQ-KPKJPENVSA-N,Agonist,Agonist,,,,,pKd,,5.65,,,,,,,,,,1323296, Retinoic acid receptor-α,590,P11416,Mouse,[3H]9-cis-retinoic acid,5383,,449171,C/C(=C/C=C/C(=C/C(=O)O)/C)/C=C/C1=C(C)CCCC1(C)C,"InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+",SHGAZHPCJJPHSC-ZVCIMWCZSA-N,Agonist,Full agonist,,,,,pKd,,9.6,,Kd,,0.24,,=,,,,8380496, Retinoic acid receptor-α,590,P10276,Human,adapalene,5429,,60164,COc1ccc(cc1C12CC3CC(C2)CC(C1)C3)c1ccc2c(c1)ccc(c2)C(=O)O,"InChI=1S/C28H28O3/c1-31-26-7-6-23(21-2-3-22-12-24(27(29)30)5-4-20(22)11-21)13-25(26)28-14-17-8-18(15-28)10-19(9-17)16-28/h2-7,11-13,17-19H,8-10,14-16H2,1H3,(H,29,30)",LZCDAPDGXCYOEH-UHFFFAOYSA-N,Agonist,Agonist,,,,,pKi,,5.96,,Ki,,1100.0,,=,Binding affinity to RARα using [3H]CD 367 as radioligand.,,,8544175, Retinoic acid receptor-α,590,P10276,Human,tazarotene,6952,,5381,CCOC(=O)c1ccc(nc1)C#Cc1ccc2c(c1)C(C)(C)CCS2,"InChI=1S/C21H21NO2S/c1-4-24-20(23)16-7-9-17(22-14-16)8-5-15-6-10-19-18(13-15)21(2,3)11-12-25-19/h6-7,9-10,13-14H,4,11-12H2,1-3H3",OGQICQVSFDPSEI-UHFFFAOYSA-N,Agonist,Agonist,,,yes,,pEC50,,7.2,,EC50,,63.0,,=,,,,19058965, Retinoic acid receptor-α,590,P10276,Human,trifarotene,9962,,11518241,OCCOc1ccc(cc1c1ccc(c(c1)C(C)(C)C)N1CCCC1)c1ccc(cc1)C(=O)O,"InChI=1S/C29H33NO4/c1-29(2,3)25-19-23(10-12-26(25)30-14-4-5-15-30)24-18-22(11-13-27(24)34-17-16-31)20-6-8-21(9-7-20)28(32)33/h6-13,18-19,31H,4-5,14-17H2,1-3H3,(H,32,33)",MFBCDACCJCDGBA-UHFFFAOYSA-N,Agonist,Agonist,,,,,pEC50,,6.3,,EC50,,500.0,,=,In a reported assay measuring activation mediated by agonist binding to the RARα ligand-binding domain.,,,29706423, Retinoic acid receptor-α,590,P10276,Human,BMS-189532,11955,,10835443,Cc1ccc(cc1)C1=CCC(C)(C)c2c1cc(cc2)C(=O)Nc1ccc(cc1)C(=O)O,"InChI=1S/C27H25NO3/c1-17-4-6-18(7-5-17)22-14-15-27(2,3)24-13-10-20(16-23(22)24)25(29)28-21-11-8-19(9-12-21)26(30)31/h4-14,16H,15H2,1-3H3,(H,28,29)(H,30,31)",WSQCBOJFDSJLNS-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKd,,7.57,,Kd,,27.0,,=,Inhibition of [3H]ATRA binding to baculovirus expressed RAR-α receptor,,,9258350,