target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id ASIC1,684,P78348,Human,Zn2+,566,,32051,,,,Channel blocker,None,ASIC1a,,,,pIC50,,8.2,,IC50,,7.0,,~,,,,15470133, ASIC1,684,P78348,Human,H+,2346,,1038,,,,Activator,None,ASIC1a,yes,,,pEC50,6.8,,6.2,EC50,630.0,,160.0,~,,,Extracellular,, ASIC1,684,P78348,Human,H+,2346,,1038,,,,Activator,None,ASIC1b,yes,,,pEC50,6.2,,5.1,EC50,8000.0,,630.0,~,,,Extracellular,, ASIC1,684,P78348,Human,amiloride,2421,,16231,NC(=NC(=O)c1nc(Cl)c(nc1N)N)N,"InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15)",XSDQTOBWRPYKKA-UHFFFAOYSA-N,Channel blocker,None,ASIC1a,,,,pIC50,,5.0,,IC50,,10000.0,,,,,,, ASIC1,684,P78348,Human,amiloride,2421,,16231,NC(=NC(=O)c1nc(Cl)c(nc1N)N)N,"InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15)",XSDQTOBWRPYKKA-UHFFFAOYSA-N,Channel blocker,None,ASIC1b,,,,pIC50,4.68,,4.64,IC50,23000.0,,21000.0,=,,,,9062189, ASIC1,684,P78348,Human,Pb2+,2525,,73212,,,,Channel blocker,None,ASIC1b,,,,pIC50,,5.8,,IC50,,1500.0,,~,,,,, ASIC1,684,P78348,Human,Pb2+,2525,,73212,,,,Channel blocker,None,ASIC1a,,,,pIC50,,5.4,,IC50,,4000.0,,~,,,,16319075, ASIC1,684,P78348,Human,ibuprofen,2713,,3672,CC(Cc1ccc(cc1)C(C(=O)O)C)C,"InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)",HEFNNWSXXWATRW-UHFFFAOYSA-N,Channel blocker,None,ASIC1a,,,,pIC50,,3.5,,IC50,,350000.0,,~,,,,11588175|28949138, ASIC1,684,P78348,Human,[125I]psalmotoxin 1,4073,,134813887,NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)O)[C@H](O)C)CCCCN)[C@H](O)C)CCCCN)C(C)C)CS)C(C)C)CCC(=O)O)Cc1ccccc1)CO)CCCN=C(N)N)CCCN=C(N)N)CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]([C@H](CC)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)N)CC(=O)O)CS)CCCCN)CCCCN)CS)CC(=O)N)CCCN=C(N)N)Cc1nc[nH]c1)CC(=O)O)CS)CS)CCC(=O)O)CC(C)C)CCC(=O)O)CS,"InChI=1S/C200H318N62O57S6/c1-13-102(10)157(257-187(309)139(95-324)251-180(302)133(83-153(280)281)242-160(282)111(206)56-60-148(270)271)194(316)261-74-36-54-142(261)189(311)239-116(46-23-28-66-203)167(289)244-128(78-106-84-221-112-42-19-17-40-109(106)112)176(298)230-114(44-21-26-64-201)161(283)223-89-147(269)229-135(91-320)185(307)255-154(99(4)5)191(313)247-131(81-144(207)266)178(300)235-121(51-33-71-219-199(212)213)168(290)246-130(80-108-86-216-97-226-108)163(285)225-88-146(268)228-132(82-152(278)279)179(301)250-138(94-323)184(306)252-136(92-321)182(304)236-123(57-61-149(272)273)162(284)224-87-145(267)227-126(76-98(2)3)174(296)237-124(58-62-150(274)275)170(292)249-137(93-322)183(305)245-129(79-107-85-222-113-43-20-18-41-110(107)113)177(299)234-115(45-22-27-65-202)164(286)231-119(49-31-69-217-197(208)209)165(287)232-120(50-32-70-218-198(210)211)166(288)233-122(52-34-72-220-200(214)215)169(291)248-134(90-263)181(303)243-127(77-105-38-15-14-16-39-105)175(297)238-125(59-63-151(276)277)173(295)254-155(100(6)7)192(314)253-140(96-325)186(308)256-156(101(8)9)193(315)260-73-35-53-141(260)188(310)240-117(47-24-29-67-204)171(293)258-158(103(11)264)195(317)262-75-37-55-143(262)190(312)241-118(48-25-30-68-205)172(294)259-159(104(12)265)196(318)319/h14-20,38-43,84-86,97-104,111,114-143,154-159,221-222,263-265,320-325H,13,21-37,44-83,87-96,201-206H2,1-12H3,(H2,207,266)(H,216,226)(H,223,283)(H,224,284)(H,225,285)(H,227,267)(H,228,268)(H,229,269)(H,230,298)(H,231,286)(H,232,287)(H,233,288)(H,234,299)(H,235,300)(H,236,304)(H,237,296)(H,238,297)(H,239,311)(H,240,310)(H,241,312)(H,242,282)(H,243,303)(H,244,289)(H,245,305)(H,246,290)(H,247,313)(H,248,291)(H,249,292)(H,250,301)(H,251,302)(H,252,306)(H,253,314)(H,254,295)(H,255,307)(H,256,308)(H,257,309)(H,258,293)(H,259,294)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,318,319)(H4,208,209,217)(H4,210,211,218)(H4,212,213,219)(H4,214,215,220)/t102-,103+,104+,111-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,154-,155-,156-,157-,158-,159-/m0/s1",KUGGGQKBZWWKLY-ACYSAVFESA-N,None,None,ASIC1a,,,,pKd,,9.7,,Kd,,0.213,,=,,,,16284080, ASIC1,684,P55926,Rat,A-317567,4116,,10200844,NC(=N)c1ccc2c(c1)ccc(c2)C1CC1c1ccc2c(c1)C(C(C)C)N(CC2)C,"InChI=1S/C27H31N3/c1-16(2)26-25-14-21(7-4-17(25)10-11-30(26)3)24-15-23(24)20-8-5-19-13-22(27(28)29)9-6-18(19)12-20/h4-9,12-14,16,23-24,26H,10-11,15H2,1-3H3,(H3,28,29)",FEPIUXBUJVISNN-UHFFFAOYSA-N,Channel blocker,None,ASIC1a,,,,pIC50,,5.7,,IC50,,2000.0,,~,,,,16061325, ASIC1,684,P78348,Human,benzamil,4145,,108107,NC(=NCc1ccccc1)NC(=O)c1nc(Cl)c(nc1N)N,"InChI=1S/C13H14ClN7O/c14-9-11(16)20-10(15)8(19-9)12(22)21-13(17)18-6-7-4-2-1-3-5-7/h1-5H,6H2,(H4,15,16,20)(H3,17,18,21,22)",KXDROGADUISDGY-UHFFFAOYSA-N,Channel blocker,None,ASIC1a,,,,pIC50,,5.0,,IC50,,10000.0,,=,,,,9062189, ASIC1,684,P78348,Human,ethylisopropylamiloride,4186,,1795,CCN(c1nc(N)c(nc1Cl)C(=O)N=C(N)N)C(C)C,"InChI=1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)",QDERNBXNXJCIQK-UHFFFAOYSA-N,Channel blocker,None,ASIC1a,,,,pIC50,,5.0,,IC50,,10000.0,,=,,,,9062189, ASIC1,684,P55926,Rat,flurbiprofen,4194,,3394,OC(=O)C(c1ccc(c(c1)F)c1ccccc1)C,"InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)",SYTBZMRGLBWNTM-UHFFFAOYSA-N,Channel blocker,None,ASIC1a,,,,pIC50,,3.5,,IC50,,350000.0,,=,,,,11588175, ASIC1,684,P78348,Human,nafamostat,4262,,4413,NC(=Nc1ccc(cc1)C(=O)Oc1ccc2c(c1)ccc(c2)C(=N)N)N,"InChI=1S/C19H17N5O2/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23/h1-10H,(H3,20,21)(H4,22,23,24)",MQQNFDZXWVTQEH-UHFFFAOYSA-N,Channel blocker,None,ASIC1a,,,,pIC50,,4.9,,IC50,,13000.0,,~,,,,17826743, ASIC1,684,P78348,Human,psalmotoxin 1,4292,,134813888,NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N)[C@H](O)C)CCCCN)[C@H](O)C)CCCCN)C(C)C)CS)C(C)C)CCC(=O)O)Cc1ccccc1)CO)CCCN=C(N)N)CCCN=C(N)N)CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]([C@H](CC)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)N)CC(=O)O)CS)CCCCN)CCCCN)CS)CC(=O)N)CCCN=C(N)N)Cc1nc[nH]c1)CC(=O)O)CS)CS)CCC(=O)O)CC(C)C)CCC(=O)O)CS,"InChI=1S/C200H319N63O56S6/c1-13-102(10)157(258-188(311)139(95-324)252-181(304)133(83-153(281)282)243-161(284)111(206)56-60-148(271)272)195(318)262-74-36-54-142(262)190(313)240-116(46-23-28-66-203)168(291)245-128(78-106-84-222-112-42-19-17-40-109(106)112)177(300)231-114(44-21-26-64-201)162(285)224-89-147(270)230-135(91-320)186(309)256-154(99(4)5)192(315)248-131(81-144(207)267)179(302)236-121(51-33-71-220-199(213)214)169(292)247-130(80-108-86-217-97-227-108)164(287)226-88-146(269)229-132(82-152(279)280)180(303)251-138(94-323)185(308)253-136(92-321)183(306)237-123(57-61-149(273)274)163(286)225-87-145(268)228-126(76-98(2)3)175(298)238-124(58-62-150(275)276)171(294)250-137(93-322)184(307)246-129(79-107-85-223-113-43-20-18-41-110(107)113)178(301)235-115(45-22-27-65-202)165(288)232-119(49-31-69-218-197(209)210)166(289)233-120(50-32-70-219-198(211)212)167(290)234-122(52-34-72-221-200(215)216)170(293)249-134(90-264)182(305)244-127(77-105-38-15-14-16-39-105)176(299)239-125(59-63-151(277)278)174(297)255-155(100(6)7)193(316)254-140(96-325)187(310)257-156(101(8)9)194(317)261-73-35-53-141(261)189(312)242-118(48-25-30-68-205)173(296)260-159(104(12)266)196(319)263-75-37-55-143(263)191(314)241-117(47-24-29-67-204)172(295)259-158(103(11)265)160(208)283/h14-20,38-43,84-86,97-104,111,114-143,154-159,222-223,264-266,320-325H,13,21-37,44-83,87-96,201-206H2,1-12H3,(H2,207,267)(H2,208,283)(H,217,227)(H,224,285)(H,225,286)(H,226,287)(H,228,268)(H,229,269)(H,230,270)(H,231,300)(H,232,288)(H,233,289)(H,234,290)(H,235,301)(H,236,302)(H,237,306)(H,238,298)(H,239,299)(H,240,313)(H,241,314)(H,242,312)(H,243,284)(H,244,305)(H,245,291)(H,246,307)(H,247,292)(H,248,315)(H,249,293)(H,250,294)(H,251,303)(H,252,304)(H,253,308)(H,254,316)(H,255,297)(H,256,309)(H,257,310)(H,258,311)(H,259,295)(H,260,296)(H,271,272)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H4,209,210,218)(H4,211,212,219)(H4,213,214,220)(H4,215,216,221)/t102-,103+,104+,111-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,154-,155-,156-,157-,158-,159-/m0/s1",OWCAPCHWSIBSKD-ACYSAVFESA-N,Channel blocker,None,ASIC1a,,,,pIC50,,9.0,,IC50,,0.9,,=,,,,10829030, ASIC1,684,P78348,Human,Pi-theraphotoxin-Hm3a,10305,,,,,,Channel blocker,None,ASIC1a,,,,pIC50,,8.5,,,,,,~,,,,28327374, ASIC1,684,P78348,Human,Pi-hexatoxin-Hi1a,10306,,,,,,Channel blocker,None,ASIC1a,,,,pIC50,,9.3,,,,,,~,,,,28320947, ASIC1,684,P78348,Human,diminazene,10307,,2354,NC(=N)c1ccc(cc1)NN=Nc1ccc(cc1)C(=N)N,"InChI=1S/C14H15N7/c15-13(16)9-1-5-11(6-2-9)19-21-20-12-7-3-10(4-8-12)14(17)18/h1-8H,(H3,15,16)(H3,17,18)(H,19,20)",XNYZHCFCZNMTFY-UHFFFAOYSA-N,Channel blocker,None,ASIC1a & ASIC1b,,,,pIC50,,6.5,,,,,,~,,,,29134638|29782492|29025967, ASIC1,684,P78348,Human,mambalgin-1,10308,,,,,,Channel blocker,None,ASIC1a,,,,pIC50,,7.3,,,,,,~,,,,23034652, ASIC1,684,P78348,Human,mambalgin-1,10308,,,,,,Channel blocker,None,ASIC1b,,,,pIC50,,7.0,,,,,,~,,,,23624383, ASIC1,684,P78348,Human,compound 5b [PMID: 25974655],11471,,122177620,CCN(CCN(c1ccc2c(c1)oc(=O)c(c2)C(=N)N)Cc1ccc(cc1)Cl)CC,"InChI=1S/C23H27ClN4O2/c1-3-27(4-2)11-12-28(15-16-5-8-18(24)9-6-16)19-10-7-17-13-20(22(25)26)23(29)30-21(17)14-19/h5-10,13-14H,3-4,11-12,15H2,1-2H3,(H3,25,26)",VVYLUODGYRRACW-UHFFFAOYSA-N,Channel blocker,None,,,,,pIC50,,7.2,,IC50,,63.0,,=,ASIC1a at pH6.7,,,25974655, ASIC1,684,P78348,Human,compound 5b [PMID: 25974655],11471,,122177620,CCN(CCN(c1ccc2c(c1)oc(=O)c(c2)C(=N)N)Cc1ccc(cc1)Cl)CC,"InChI=1S/C23H27ClN4O2/c1-3-27(4-2)11-12-28(15-16-5-8-18(24)9-6-16)19-10-7-17-13-20(22(25)26)23(29)30-21(17)14-19/h5-10,13-14H,3-4,11-12,15H2,1-2H3,(H3,25,26)",VVYLUODGYRRACW-UHFFFAOYSA-N,Channel blocker,None,,,,,pIC50,,5.2,,IC50,,6310.0,,=,ASIC1a at pH5.0,,,25974655, ASIC1,684,P78348,Human,JNJ-799760,11472,,155289267,COc1ccc(cc1OC)Oc1ccc(cc1)c1[nH]c2c(n1)cc(cc2)C(=N)N,"InChI=1S/C22H20N4O3/c1-27-19-10-8-16(12-20(19)28-2)29-15-6-3-13(4-7-15)22-25-17-9-5-14(21(23)24)11-18(17)26-22/h3-12H,1-2H3,(H3,23,24)(H,25,26)",QMVSFWHTZQVRCC-UHFFFAOYSA-N,Channel blocker,None,,,,,pIC50,,7.6,,IC50,,25.1,,=,ASIC1a at pH6.0,,,33564124, ASIC1,684,P78348,Human,JNJ-67869386,11473,,155817525,Cc1ncc(c(c1)N1CC(C1)Oc1cc(F)c2c(c1)[nH]nc2N)F,"InChI=1S/C16H15F2N5O/c1-8-2-14(12(18)5-20-8)23-6-10(7-23)24-9-3-11(17)15-13(4-9)21-22-16(15)19/h2-5,10H,6-7H2,1H3,(H3,19,21,22)",YINCAUPIZHIQGR-UHFFFAOYSA-N,Channel blocker,None,,,,,pIC50,,7.5,,IC50,,31.6,,=,ASIC1a at pH6.0,,,33564124, ASIC1,684,P78348,Human,NS383,11474,,135418391,CCN1CCc2c(C1)c1NC(=O)/C(=N/O)/c1cc2c1ccccc1,"InChI=1S/C19H19N3O2/c1-2-22-9-8-13-14(12-6-4-3-5-7-12)10-15-17(16(13)11-22)20-19(23)18(15)21-24/h3-7,10,24H,2,8-9,11H2,1H3,(H,20,21,23)",CHVQAXYXYIDNDC-UHFFFAOYSA-N,Channel blocker,None,,,,,pIC50,,6.4,,IC50,,398.0,,=,ASIC1a at pH6.5,,,26663905, ASIC1,684,P78348,Human,ASC06-IgG1,12564,,,,,,Channel blocker,Inhibition,,,,,pIC50,,7.1,,IC50,,79.0,,~,,,,30042215,