target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id ENaCαβγ,742,,Human,amiloride,2421,,16231,NC(=NC(=O)c1nc(Cl)c(nc1N)N)N,"InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15)",XSDQTOBWRPYKKA-UHFFFAOYSA-N,Channel blocker,None,,,yes,,pIC50,7.0,,6.7,IC50,200.0,,100.0,=,,,,, ENaCαβγ,742,,Human,benzamil,4145,,108107,NC(=NCc1ccccc1)NC(=O)c1nc(Cl)c(nc1N)N,"InChI=1S/C13H14ClN7O/c14-9-11(16)20-10(15)8(19-9)12(22)21-13(17)18-6-7-4-2-1-3-5-7/h1-5H,6H2,(H4,15,16,20)(H3,17,18,21,22)",KXDROGADUISDGY-UHFFFAOYSA-N,Channel blocker,None,,,,,pIC50,,8.0,,IC50,,10.0,,~,,,,, ENaCαβγ,742,,Human,P552-02,4280,,10310524,OCC(COc1ccc(cc1)CCCCN=C(NC(=O)c1nc(Cl)c(nc1N)N)N)O,"InChI=1S/C19H26ClN7O4/c20-15-17(22)26-16(21)14(25-15)18(30)27-19(23)24-8-2-1-3-11-4-6-13(7-5-11)31-10-12(29)9-28/h4-7,12,28-29H,1-3,8-10H2,(H4,21,22,26)(H3,23,24,27,30)",NTRKMGDUWYBLMS-UHFFFAOYSA-N,Channel blocker,None,,,,,pIC50,,8.1,,IC50,,7.6,,=,,,,, ENaCαβγ,742,,Human,S3969,4305,,46861536,OCCNC(=O)C(Sc1c[nH]c2c1c(C)ccc2)CC(C)C,"InChI=1S/C17H24N2O2S/c1-11(2)9-14(17(21)18-7-8-20)22-15-10-19-13-6-4-5-12(3)16(13)15/h4-6,10-11,14,19-20H,7-9H2,1-3H3,(H,18,21)",FTNIWEHRMFLJKE-UHFFFAOYSA-N,Activator,None,,,,,pEC50,,5.9,,EC50,,1200.0,,=,,,,18326490, ENaCαβγ,742,,Human,triamterene,4329,,5546,Nc1nc(N)c2c(n1)nc(c(n2)c1ccccc1)N,"InChI=1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)",FNYLWPVRPXGIIP-UHFFFAOYSA-N,Channel blocker,None,,,yes,,pIC50,,5.3,,IC50,,5000.0,,~,,,,8107805|14500741, ENaCαβγ,742,,Mouse,BI1265162,11717,,126619641,CCn1c(CNC(=O)c2nc(Cl)cnc2N)[n+](CC)c2ccc(OCC(=O)NCCOCP(=O)(C)C)cc12,"InChI=1S/C24H33ClN7O5P/c1-5-31-17-8-7-16(37-14-20(33)27-9-10-36-15-38(3,4)35)11-18(17)32(6-2)21(31)13-29-24(34)22-23(26)28-12-19(25)30-22/h7-8,11-12H,5-6,9-10,13-15H2,1-4H3,(H3-,26,27,28,29,33,34)/p+1",DXVNYGRCASBPNU-UHFFFAOYSA-O,Inhibitor,Inhibition,,,,,pIC50,,8.52,,IC50,,3.0,,=,Inhibition of ENac current in mouse kidney M-l cells in the Ussing chamber assay.,,,,