target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id ATP4A,849,P20648,Human,omeprazole,4279,,4594,COc1ccc2c(c1)nc([nH]2)S(=O)Cc1ncc(c(c1C)OC)C,"InChI=1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)",SUBDBMMJDZJVOS-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,,,,,,,,,=,,,,, ATP4A,849,P20648,Human,esomeprazole,5488,,9568614,COc1ccc2c(c1)[nH]c(n2)[S@@](=O)Cc1ncc(c(c1C)OC)C,"InChI=1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)/t24-/m0/s1",SUBDBMMJDZJVOS-DEOSSOPVSA-N,Inhibitor,Inhibition,,,yes,,,,,,,,,,=,,,,, ATP4A,849,,Rabbit,ilaprazole,10512,,214351,COc1ccnc(c1C)CS(=O)c1nc2c([nH]1)cc(cc2)n1cccc1,"InChI=1S/C19H18N4O2S/c1-13-17(20-8-7-18(13)25-2)12-26(24)19-21-15-6-5-14(11-16(15)22-19)23-9-3-4-10-23/h3-11H,12H2,1-2H3,(H,21,22)",HRRXCXABAPSOCP-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.05,,IC50,,9.0,,=,Measuring inhibition of histamine-induced accumulation of 14C-aminopyrine in rabbit parietal cells.,,,11304936, ATP4A,849,,Pig,vonoprazan,11549,,15981397,CNCc1cc(n(c1)S(=O)(=O)c1cccnc1)c1ccccc1F,"InChI=1S/C17H16FN3O2S/c1-19-10-13-9-17(15-6-2-3-7-16(15)18)21(12-13)24(22,23)14-5-4-8-20-11-14/h2-9,11-12,19H,10H2,1H3",BFDBKMOZYNOTPK-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.72,,IC50,,19.0,,=,Inhibition of H+/K+-ATPase activity in a gastric mucosal membrane microsomal fraction from pig stomach.,,,22512618, ATP4A,849,,Pig,revaprazan,12007,,204104,CC1c2ccccc2CCN1c1nc(nc(c1C)C)Nc1ccc(cc1)F,"InChI=1S/C22H23FN4/c1-14-15(2)24-22(25-19-10-8-18(23)9-11-19)26-21(14)27-13-12-17-6-4-5-7-20(17)16(27)3/h4-11,16H,12-13H2,1-3H3,(H,24,25,26)",LECZXZOBEZITCL-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.46,,IC50,,350.0,,=,Inhibitory activity against H+/K+ ATPase isolated from hog gastric mucosa,,,20810280, ATP4A,849,,Pig,revaprazan,12007,,204104,CC1c2ccccc2CCN1c1nc(nc(c1C)C)Nc1ccc(cc1)F,"InChI=1S/C22H23FN4/c1-14-15(2)24-22(25-19-10-8-18(23)9-11-19)26-21(14)27-13-12-17-6-4-5-7-20(17)16(27)3/h4-11,16H,12-13H2,1-3H3,(H,24,25,26)",LECZXZOBEZITCL-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,5.64,,IC50,,2300.0,,=,,,,35604136, ATP4A,849,P20648,Human,tegoprazan,12008,,23582846,Cc1nc2c([nH]1)cc(cc2O[C@H]1CCOc2c1c(cc(c2)F)F)C(=O)N(C)C,"InChI=1S/C20H19F2N3O3/c1-10-23-14-6-11(20(26)25(2)3)7-17(19(14)24-10)28-15-4-5-27-16-9-12(21)8-13(22)18(15)16/h6-9,15H,4-5H2,1-3H3,(H,23,24)/t15-/m0/s1",CLIQCDHNPDMGSL-HNNXBMFYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.28,,IC50,,520.0,,=,Inhibition of the H+/K+-ATPase activity of recombinant human enzyme,,,29180359,