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CINCA syndrome

Disease ID:1026
Name:CINCA syndrome
Associated with:1 target
1 immuno-relevant ligand
Synonyms
Chronic infantile neurological cutaneous articular syndrome
Database Links
OMIM: 607115
Orphanet: ORPHA1451

Targets

NLRP3

Ligands

Key to terms and symbols Click ligand name to view ligand summary Click column headers to sort
Ligand References Clinical and Disease comments
rilonacept
Immuno Disease Comments: Approved drug for CINCA syndrome.
Clinical Use: Currently used in the treatment of cryopyrin-associated periodic syndrome (CAPS). Cryopyrin-associated periodic syndrome includes three previously distinct disorders: Familial cold autoinflammatory syndrome; Muckle-Wells syndrome; and CINCA syndrome, that are now considered to represent a disease continuum, all caused by NLRP3 protein mutations.

EMA approval has been withdrawn. | View clinical data