Atherosclerosis susceptibility
GtoPdb Disease Summaries
This section gives an overview of the disease, and where available shows the following:
- Synonyms: Shows known synonyms for the disease.
- Description: Gives a basic description/definition of the disease.
- Database Link: External links to the same disease at the Disease Ontology, OMIM or Orphanet sites.
- Immunopharmacology comments: General comments about the target's role in immunopharmacology, provided by GtoImmuPdb curators.
- Associated with: Counts are displayed for the total targets the disease is associated with in GtoPdb. The counts of targets and ligands of immunological relevance associated to the disease are also shown.
More information can be found in the help pages.
✖| Disease ID: | 92 | |
| Name: | Atherosclerosis susceptibility | |
| Associated with: | 7 targets | |
Targets
GtoPdb Disease Summaries - Targets
Click on the target name to link to its detailed view page
Where available, information is display on the role of the target in the disease; drugs which target the disease and their therapeutic use and side-effects.
If there is mutation data curated in GtoPdb this is indicated, with a link back to the appropriate section on the target detailed view page
Immuno ligand interactions - If available, a table of immuno-relevant ligands is shown. These ligands have been curated as having an association to the disease and possess interaction data with the target in GtoPdb. The approval status of the ligand is shown, along with curator comments and an indication of whether the target is considered the primary target of the ligand.
More information can be found in the help pages.
✖| BLT1 receptor | |
| References: | 1-3,12 |
| Peroxisome proliferator-activated receptor-β/δ | |
| Role: | Controversial |
| Comments: | Deletion of PPAR-beta/delta from foam cells increases the availability of inflammatory suppressors, which in turn reduces atherosclerotic lesion area, but Li et al. show that PPAR beta specific agonist failed to inhibit lesion formation. |
| References: | 4-5,7-8 |
| Peroxisome proliferator-activated receptor-γ | |
| Comments: | Alteration at the receptor level: stimulated expression in atherosclerotic lesions, in macrophages and monocytic cell lines |
| References: | 6,11 |
| TLR4 |
| TLR8 |
| NLRP3 |
| regulator of G-protein signaling 1 | |
| Comments: | Vascular diseases: Atherosclerosis AND aortic aneurysms |
| References: | 9-10 |
Ligands
GtoPdb Disease Summaries - Ligands
Click ligand name to view ligand summary page
- Approved: If the ligand is an approved drug this is indicated, along with approval bodies.
- Immuno: Immuno icon indicates the ligand is immuno-relevant
Click the arrow in the final column to expand comments
- Immuno Disease Comments: Curatorial comments specifically added as part of GtoImmuPdb. They give more information on the association between the ligand and disease in the context of immunopharmacology.
- Clinical Use: General clinical comments relating to the ligand and may not necessarily be specific to the disease in question. With hyperlink to more details on the ligand summary pages.
- Bioactivty Comments: Curatorial comments specifically about the compounds biological activity - with hyperlink to more details on the ligand summary pages.
More information can be found in the help pages.
✖No ligand related data available for Atherosclerosis susceptibility
References
1. Aiello RJ, Bourassa PA, Lindsey S, Weng W, Freeman A, Showell HJ. (2002) Leukotriene B4 receptor antagonism reduces monocytic foam cells in mice. Arterioscler Thromb Vasc Biol, 22 (3): 443-9. [PMID:11884288]
2. Bäck M, Bu DX, Bränström R, Sheikine Y, Yan ZQ, Hansson GK. (2005) Leukotriene B4 signaling through NF-kappaB-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia. Proc Natl Acad Sci USA, 102 (48): 17501-6. [PMID:16293697]
3. Bäck M, Hansson GK. (2006) Leukotriene receptors in atherosclerosis. Ann Med, 38 (7): 493-502. [PMID:17101540]
4. Desvergne B, Michalik L, Wahli W. (2004) Be fit or be sick: peroxisome proliferator-activated receptors are down the road. Mol Endocrinol, 18 (6): 1321-32. [PMID:15087471]
5. Graham TL, Mookherjee C, Suckling KE, Palmer CN, Patel L. (2005) The PPARdelta agonist GW0742X reduces atherosclerosis in LDLR(-/-) mice. Atherosclerosis, 181 (1): 29-37. [PMID:15939051]
6. Kersten S, Desvergne B, Wahli W. (2000) Roles of PPARs in health and disease. Nature, 405 (6785): 421-4. [PMID:10839530]
7. Lee CH, Chawla A, Urbiztondo N, Liao D, Boisvert WA, Evans RM, Curtiss LK. (2003) Transcriptional repression of atherogenic inflammation: modulation by PPARdelta. Science, 302 (5644): 453-7. [PMID:12970571]
8. Li AC, Binder CJ, Gutierrez A, Brown KK, Plotkin CR, Pattison JW, Valledor AF, Davis RA, Willson TM, Witztum JL, Palinski W, Glass CK. (2004) Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma. J Clin Invest, 114 (11): 1564-76. [PMID:15578089]
9. Patel J, Channon KM, McNeill E. (2013) The downstream regulation of chemokine receptor signalling: implications for atherosclerosis. Mediators Inflamm, 2013: 459520. [PMID:23690662]
10. Patel J, McNeill E, Douglas G, Hale AB, de Bono J, Lee R, Iqbal AJ, Regan-Komito D, Stylianou E, Greaves DR et al.. (2015) RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling. Nat Commun, 6: 6614. [PMID:25782711]
11. Ricote M, Huang J, Fajas L, Li A, Welch J, Najib J, Witztum JL, Auwerx J, Palinski W, Glass CK. (1998) Expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein. Proc Natl Acad Sci USA, 95 (13): 7614-9. [PMID:9636198]
12. Subbarao K, Jala VR, Mathis S, Suttles J, Zacharias W, Ahamed J, Ali H, Tseng MT, Haribabu B. (2004) Role of leukotriene B4 receptors in the development of atherosclerosis: potential mechanisms. Arterioscler Thromb Vasc Biol, 24 (2): 369-75. [PMID:14656734]
