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5-Hydroxytryptamine receptors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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5-HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors [65] and subsequently revised [59]) are, with the exception of the ionotropic 5-HT3 class, GPCRs where the endogenous agonist is 5-hydroxytryptamine. The diversity of metabotropic 5-HT receptors is increased by alternative splicing that produces isoforms of the 5-HT2A (non-functional), 5-HT2C (non-functional), 5-HT4, 5-HT6 (non-functional) and 5-HT7 receptors. Unique amongst the GPCRs, RNA editing produces 5-HT2C receptor isoforms that differ in function, such as efficiency and specificity of coupling to Gq/11 and also pharmacology [14,159]. Most 5-HT receptors (except 5-ht1e and 5-ht5b) play specific roles mediating functional responses in different tissues (reviewed by [125,150]).

Receptors

5-HT1A receptor C Show summary » More detailed page

5-HT1B receptor C Show summary » More detailed page

5-HT1D receptor C Show summary » More detailed page

5-ht1e receptor C Show summary » More detailed page

5-HT1F receptor C Show summary » More detailed page

5-HT2A receptor C Show summary » More detailed page

5-HT2B receptor C Show summary » More detailed page

5-HT2C receptor C Show summary » More detailed page

5-HT4 receptor C Show summary » More detailed page

5-HT5A receptor C Show summary » More detailed page

5-ht5b receptor C Show summary » More detailed page

5-HT6 receptor C Show summary » More detailed page

5-HT7 receptor C Show summary » More detailed page

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: G protein-coupled receptors. Br J Pharmacol. 174 Suppl 1: S17-S129.