Nucleotide turnover

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Nucleotide turnover

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

dihydropyrimidine dehydrogenase Show summary »« Hide summary More detailed page

Target Id

3102

Nomenclature

dihydropyrimidine dehydrogenase

Previous and unofficial names

DHPDHase | dihydropyrimidine dehydrogenase [NADP(+)] | DPD

Genes

DPYD (Hs), Dpyd (Mm), Dpyd (Rn)

Ensembl ID

ENSG00000188641 (Hs), ENSMUSG00000033308 (Mm)

UniProtKB AC

Q12882 (Hs), Q8CHR6 (Mm), O89000 (Rn)

EC number

1.3.1.2

Comment

Dihydropyrimidine dehydrogenase is required for the first and rate-limiting step of pyrimidine catabolism. In addition to degrading pyrimidines, it also breaks down pyrimidine-based 5-fluorouracil, the anticancer cytostatic agent that is produced from chemotherapeutic prodrugs including capecitabine and tegafur.

How to cite this family page

Database page citation:

Nucleotide turnover. Accessed on 07/07/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1029.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.