P2B P-type ATPases: Ca<sup>2+</sup>-ATPases | Transporters

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P2B P-type ATPases: Ca²⁺-ATPases

P2B P-type ATPases: Ca²⁺-ATPases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Transporters

PMCA1 Show summary »« Hide summary

Target Id

843

Nomenclature

PMCA1

Previous and unofficial names

Genes

ATP2B1 (Hs), Atp2b1 (Mm), Atp2b1 (Rn)

Ensembl ID

ENSG00000070961 (Hs), ENSMUSG00000019943 (Mm), ENSRNOG00000004026 (Rn)

UniProtKB AC

P20020 (Hs), P11505 (Rn)

EC number

3.6.3.8

PMCA2 Show summary »« Hide summary

Target Id

844

Nomenclature

PMCA2

Previous and unofficial names

Genes

ATP2B2 (Hs), Atp2b2 (Mm), Atp2b2 (Rn)

Ensembl ID

ENSG00000157087 (Hs), ENSMUSG00000030302 (Mm), ENSRNOG00000030269 (Rn)

UniProtKB AC

Q01814 (Hs), Q9R0K7 (Mm), P11506 (Rn)

EC number

3.6.3.8

PMCA3 Show summary »« Hide summary

Target Id

845

Nomenclature

PMCA3

Previous and unofficial names

Plasma membrane calcium ATPase isoform 3 | plasma membrane calcium-transporting ATPase 3 | ATPase, Ca++ transporting, plasma membrane 3 | ATPase, Ca� transporting, plasma membrane 3 | ATPase

Genes

ATP2B3 (Hs), Atp2b3 (Mm), Atp2b3 (Rn)

Ensembl ID

ENSG00000067842 (Hs), ENSMUSG00000031376 (Mm), ENSRNOG00000017798 (Rn)

UniProtKB AC

Q16720 (Hs), Q64568 (Rn)

EC number

3.6.3.8

PMCA4 Show summary »« Hide summary

Target Id

846

Nomenclature

PMCA4

Previous and unofficial names

Genes

ATP2B4 (Hs), Atp2b4 (Mm), Atp2b4 (Rn)

Ensembl ID

ENSG00000058668 (Hs), ENSMUSG00000026463 (Mm), ENSRNOG00000003031 (Rn)

UniProtKB AC

P23634 (Hs), Q64542 (Rn)

EC number

3.6.3.8

SPCA1 Show summary »« Hide summary

Target Id

847

Nomenclature

SPCA1

Previous and unofficial names

Genes

ATP2C1 (Hs), Atp2c1 (Mm), Atp2c1 (Rn)

Ensembl ID

ENSG00000017260 (Hs), ENSMUSG00000032570 (Mm), ENSRNOG00000013305 (Rn)

UniProtKB AC

P98194 (Hs), Q80XR2 (Mm), Q64566 (Rn)

EC number

3.6.3.8

SPCA2 Show summary »« Hide summary

Target Id

848

Nomenclature

SPCA2

Previous and unofficial names

Genes

ATP2C2 (Hs), Atp2c2 (Mm), Atp2c2 (Rn)

Ensembl ID

ENSG00000064270 (Hs), ENSMUSG00000034112 (Mm), ENSRNOG00000049334 (Rn)

UniProtKB AC

O75185 (Hs), A7L9Z8 (Mm), Q8R4C1 (Rn)

EC number

3.6.3.8

synaptic vesicle glycoprotein 2A / SLC22B1 C Show summary »« Hide summary More detailed page go icon to follow link

neuroplastin C Show summary »« Hide summary

PDZ domain containing 11 C Show summary »« Hide summary

Target Id	3150
Nomenclature	PDZ domain containing 11
Previous and unofficial names	AIPP1 \| ATPase-interacting PDZ protein \| PISP \| PMCA-interacting single-PDZ protein \| Pdzk11
Genes	PDZD11 (Hs), Pdzd11 (Mm), Pdzd11 (Rn)
Ensembl ID	ENSG00000120509 (Hs), ENSMUSG00000015668 (Mm), ENSRNOG00000002838 (Rn)
UniProtKB AC	Q5EBL8 (Hs), Q9CZG9 (Mm)

erythrocyte membrane protein band 4.1 C Show summary »« Hide summary

Target Id	3151
Nomenclature	erythrocyte membrane protein band 4.1
Genes	EPB41 (Hs), Epb41 (Mm), Epb41 (Rn)
Ensembl ID	ENSG00000159023 (Hs), ENSMUSG00000028906 (Mm), ENSRNOG00000010037 (Rn)
UniProtKB AC	P11171 (Hs), P48193 (Mm)
Comment	A major structural element of the erythrocyte membrane skeleton that controls erythrocyte shape and deformability [1]; mutations the gene cause hereditary type 1 elliptocytosis, characterised by elliptically shaped erythrocytes and variable hemolytic anaemia.

References

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1. Conboy J, Kan YW, Shohet SB, Mohandas N. (1986) Molecular cloning of protein 4.1, a major structural element of the human erythrocyte membrane skeleton. Proc Natl Acad Sci U S A, 83 (24): 9512-6. [PMID:3467321]

2. Kenda BM, Matagne AC, Talaga PE, Pasau PM, Differding E, Lallemand BI, Frycia AM, Moureau FG, Klitgaard HV, Gillard MR et al.. (2004) Discovery of 4-substituted pyrrolidone butanamides as new agents with significant antiepileptic activity. J Med Chem, 47 (3): 530-49. [PMID:14736235]

3. Madeo M, Kovács AD, Pearce DA. (2014) The human synaptic vesicle protein, SV2A, functions as a galactose transporter in Saccharomyces cerevisiae. J Biol Chem, 289 (48): 33066-71. [PMID:25326386]

4. Noyer M, Gillard M, Matagne A, Hénichart JP, Wülfert E. (1995) The novel antiepileptic drug levetiracetam (ucb L059) appears to act via a specific binding site in CNS membranes. Eur J Pharmacol, 286 (2): 137-46. [PMID:8605950]

How to cite this family page

Database page citation:

P2B P-type ATPases: Ca²⁺-ATPases. Accessed on 12/04/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1045.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.

P2B P-type ATPases: Ca2+-ATPases C

Transporters

References

How to cite this family page

P2B P-type ATPases: Ca²⁺-ATPases C