Folate biosynthesis enzymes

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Targets

PfDHFR-TS (Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2981
Nomenclature	Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase
Common abbreviation	PfDHFR-TS
Previous and unofficial names	DHFR-TS \| Pf3D7_04_v3:747,897..750,065(+) \| PFD0830w
Genes	DHFR-TS (Pf3D7)
UniProtKB AC	Q8I1R6 (Pf3D7)
PlasmoDB	PF3D7_0417200 (Pf3D7)

PfPPPK-DHPS (Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3065
Nomenclature	Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase
Common abbreviation	PfPPPK-DHPS
Previous and unofficial names	PPPK-DHPS \| Pf3D7_08_v3:547,896..551,057(+) \| PF08_0095
Genes	PPPK-DHPS (Pf3D7)
UniProtKB AC	Q8IAU3 (Pf3D7)
PlasmoDB	PF3D7_0810800 (Pf3D7)

PfSHMT (Plasmodium falciparum serine hydroxymethyltransferase) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3066
Nomenclature	Plasmodium falciparum serine hydroxymethyltransferase
Common abbreviation	PfSHMT
Previous and unofficial names	SHMT \| Pf3D7_12_v3:1,483,501..1,486,097(+) \| PFL1720w
Genes	SHMT (Pf3D7)
UniProtKB AC	Q8I566 (Pf3D7)
PlasmoDB	PF3D7_1235600 (Pf3D7)

How to cite this family page

Database page citation:

Folate biosynthesis enzymes. Accessed on 03/04/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1051.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Cidlowski JA, Davenport AP, Fabbro D, Spedding M, Striessnig J, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Introduction and Other Protein Targets. Br J Pharmacol. 182: S1-S23.