CYP2 family: physiological enzymes subset | Enzymes | IUPHAR/BPS Guide to PHARMACOLOGY

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CYP2 family: physiological enzymes subset

CYP2 family: physiological enzymes subset C

Overview

Compared to the other CYP2 family enzymes, this subset have physiological rather than drug metabolising enzyme activities.

Enzymes

CYP2R1 C Show summary »« Hide summary

Target Id

1333

Nomenclature

CYP2R1

Previous and unofficial names

Vitamin D 25-hydroxylase | cytochrome P450, family 2, subfamily R, polypeptide 1 | cytochrome P450, family 2, subfamily r, polypeptide 1 | cytochrome P450

Genes

CYP2R1 (Hs), Cyp2r1 (Mm), Cyp2r1 (Rn)

Ensembl ID

ENSG00000186104 (Hs), ENSMUSG00000030670 (Mm), ENSRNOG00000011367 (Rn)

UniProtKB AC

Q6VVX0 (Hs), Q6VVW9 (Mm)

EC number

1.14.13.15

Comment

Converts vitamin D3 to calcifediol [1]. Expressed in CD34⁺ human cord blood hematopoietic stem and early progenitor cells [8].

CYP2S1 C Show summary »« Hide summary

Target Id

1334

Nomenclature

CYP2S1

Previous and unofficial names

cytochrome P450, family 2, subfamily s, polypeptide 1 | cytochrome P450, family 2, subfamily S, polypeptide 1 | cytochrome P450

Genes

CYP2S1 (Hs), Cyp2s1 (Mm), Cyp2s1 (Rn)

Ensembl ID

ENSG00000167600 (Hs), ENSMUSG00000040703 (Mm), ENSRNOG00000020743 (Rn)

UniProtKB AC

Q96SQ9 (Hs), Q9DBX6 (Mm)

EC number

1.14.14.1

Comment

Considered an orphan CYP [9]. Possibly involved in polyunsaturated fatty acid ω-1 hydroxylation [5].

CYP2U1 C Show summary »« Hide summary

Target Id

1335

Nomenclature

CYP2U1

Previous and unofficial names

cytochrome P450 2U1 | cytochrome P450, family 2, subfamily u, polypeptide 1 | cytochrome P450, family 2, subfamily U, polypeptide 1 | cytochrome P450

Genes

CYP2U1 (Hs), Cyp2u1 (Mm), Cyp2u1 (Rn)

Ensembl ID

ENSG00000155016 (Hs), ENSMUSG00000027983 (Mm), ENSRNOG00000011053 (Rn)

UniProtKB AC

Q7Z449 (Hs), Q9CX98 (Mm), Q4V8D1 (Rn)

EC number

1.14.14.1

Comment

Thymus and brain specific catalysis of ω- and (ω-1)-hydroxylation of fatty acids [2]. Oxidation of N-arachidonoylserotonin [7]. Mutations have been associated with hereditary spastic paraplegia [4].

CYP2W1 C Show summary »« Hide summary

Target Id

1336

Nomenclature

CYP2W1

Previous and unofficial names

cytochrome P450, family 2, subfamily W, polypeptide 1 | cytochrome P450, family 2, subfamily w, polypeptide 1 | cytochrome P450

Genes

CYP2W1 (Hs), Cyp2w1 (Mm), Cyp2w1 (Rn)

Ensembl ID

ENSG00000073067 (Hs), ENSMUSG00000029541 (Mm), ENSRNOG00000051770 (Rn)

UniProtKB AC

Q8TAV3 (Hs)

EC number

1.14.14.-

Comment

Appears to have cancer specific expression [6]. Potential drug target in colorectal cancer [3].

References

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1. Cheng JB, Motola DL, Mangelsdorf DJ, Russell DW. (2003) De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase. J Biol Chem, 278 (39): 38084-93. [PMID:12867411]

2. Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B. (2004) CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids. J Biol Chem, 279 (8): 6305-14. [PMID:14660610]

3. Chung FF, Mai CW, Ng PY, Leong CO. (2016) Cytochrome P450 2W1 (CYP2W1) in Colorectal Cancers. Curr Cancer Drug Targets, 16 (1): 71-8. [PMID:26563883]

4. Dhers L, Ducassou L, Boucher JL, Mansuy D. (2017) Cytochrome P450 2U1, a very peculiar member of the human P450s family. Cell Mol Life Sci, 74 (10): 1859-1869. [PMID:28083596]

5. Fekry MI, Xiao Y, Berg JZ, Guengerich FP. (2019) A Role for the Orphan Human Cytochrome P450 2S1 in Polyunsaturated Fatty Acid ω-1 Hydroxylation Using an Untargeted Metabolomic Approach. Drug Metab Dispos, 47 (11): 1325-1332. [PMID:31511258]

6. Pan Y, Ong EC. (2017) Cytochrome P450 2W1 (CYP2W1) - ready for use as the biomarker and drug target for cancer?. Xenobiotica, 47 (10): 923-932. [PMID:27690753]

7. Siller M, Goyal S, Yoshimoto FK, Xiao Y, Wei S, Guengerich FP. (2014) Oxidation of endogenous N-arachidonoylserotonin by human cytochrome P450 2U1. J Biol Chem, 289 (15): 10476-87. [PMID:24563460]

8. Xu S, Ren Z, Wang Y, Ding X, Jiang Y. (2014) Preferential expression of cytochrome CYP CYP2R1 but not CYP1B1 in human cord blood hematopoietic stem and progenitor cells. Acta Pharm Sin B, 4 (6): 464-9. [PMID:26579418]

9. Yan P, Eng OC, Yu CJ. (2018) A Review on the Expression and Metabolic Features of Orphan Human Cytochrome P450 2S1 (CYP2S1). Curr Drug Metab, 19 (11): 917-929. [PMID:29804525]

NC-IUPHAR subcommittee and family contributors

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Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.