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β-catenin destruction complex proteins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The β-catenin destruction multiprotein complex negatively regulates the canonical Wnt signalling pathway by targeting β-catenin for ubiquitination and proteasomal degradation. The complex includes axin, adenomatosis polyposis coli (APC), protein phosphatase 2A (PP2A) and glycogen synthase kinase 3 (GSK3).

Targets

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axin 2 Show summary »

References

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How to cite this family page

Database page citation:

β-catenin destruction complex proteins. Accessed on 30/05/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1081.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.