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Mono-ADP-ribosylating PARPs C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The enzymes in this subfamily of mono-ADP-ribosylating (MARylating) PARPs are encoded by 11 genes in humans. In published literature these enzymes may be referred to as 'mono-ARTs'. We have included here those enzymes for which small molecule modulators have been reported. Of note is the PARP7 (TIPARP) inhibitor atamparib (RBN2397) that is in clinical trial as an antineoplastic for solid tumours.

Enzymes

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PARP3 (poly (ADP-ribose) polymerase 3) C Show summary » More detailed page go icon to follow link

PARP7 (TCDD inducible poly(ADP-ribose) polymerase) C Show summary »

poly(ADP-ribose) polymerase family member 10 Show summary »

poly(ADP-ribose) polymerase family member 11 Show summary »

poly(ADP-ribose) polymerase family member 14 Show summary »

poly(ADP-ribose) polymerase family member 15 Show summary »

References

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How to cite this family page

Database page citation:

Mono-ADP-ribosylating PARPs. Accessed on 24/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1096.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.