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- Transporters
- SLC superfamily of solute carriers
- SLC25 family of mitochondrial transporters
- SLC25 mitochondrial vitamin and co-factor carriers subfamily
SLC25 mitochondrial vitamin and co-factor carriers subfamily C
Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Transporters
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TPC (Thiamine pyrophosphate carrier / SLC25A19) C Show summary »« Hide summary
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PLPC (Pyridoxal 5′-phosphate carrier / SLC25A38) C Show summary »« Hide summary
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SAMC (S-Adenosylmethionine carrier / SLC25A26) C Show summary »« Hide summary
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FLXC (Folate carrier / SLC25A32) C Show summary »« Hide summary
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NADT1 (Mitochondrial nicotinamide adenine dinucleotide transporter 1 / SLC25A51) C Show summary »« Hide summary
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NADT2 (Mitochondrial nicotinamide adenine dinucleotide transporter 2 / SLC25A52) C Show summary »« Hide summary
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GSHC1 (Mitochondrial glutathione transporter 1 / SLC25A39) C Show summary »« Hide summary
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Mitochondrial glutathione transporter 2 / SLC25A40 C Show summary »« Hide summary
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CoAT (Mitochondrial Coenzyme A transporter / SLC25A42) C Show summary »« Hide summary
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References
1. Agrimi G, Di Noia MA, Marobbio CM, Fiermonte G, Lasorsa FM, Palmieri F. (2004) Identification of the human mitochondrial S-adenosylmethionine transporter: bacterial expression, reconstitution, functional characterization and tissue distribution. Biochem J, 379 (Pt 1): 183-90. [PMID:14674884]
2. Fiermonte G, Paradies E, Todisco S, Marobbio CM, Palmieri F. (2009) A novel member of solute carrier family 25 (SLC25A42) is a transporter of coenzyme A and adenosine 3',5'-diphosphate in human mitochondria. J Biol Chem, 284 (27): 18152-9. [PMID:19429682]
3. Girardi E, Agrimi G, Goldmann U, Fiume G, Lindinger S, Sedlyarov V, Srndic I, Gürtl B, Agerer B, Kartnig F et al.. (2020) Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import. Nat Commun, 11 (1): 6145. [PMID:33262325]
4. Kory N, Uit de Bos J, van der Rijt S, Jankovic N, Güra M, Arp N, Pena IA, Prakash G, Chan SH, Kunchok T et al.. (2020) MCART1/SLC25A51 is required for mitochondrial NAD transport. Sci Adv, 6 (43). [PMID:33087354]
5. Lindhurst MJ, Fiermonte G, Song S, Struys E, De Leonardis F, Schwartzberg PL, Chen A, Castegna A, Verhoeven N, Mathews CK et al.. (2006) Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia. Proc Natl Acad Sci U S A, 103 (43): 15927-32. [PMID:17035501]
6. Luongo TS, Eller JM, Lu MJ, Niere M, Raith F, Perry C, Bornstein MR, Oliphint P, Wang L, McReynolds MR et al.. (2020) SLC25A51 is a mammalian mitochondrial NAD+ transporter. Nature, 588 (7836): 174-179. [PMID:32906142]
7. Pena IA, Shi JS, Chang SM, Yang J, Block S, Adelmann CH, Keys HR, Ge P, Bathla S, Witham IH et al.. (2025) SLC25A38 is required for mitochondrial pyridoxal 5'-phosphate (PLP) accumulation. Nat Commun, 16 (1): 978. [PMID:39856062]
8. Shi X, DeCiucis M, Grabinska KA, Kanyo J, Liu A, Lam TT, Shen H. (2024) Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis. Mol Cell, 84 (4): 802-810.e6. [PMID:38157846]
9. Shi X, Reinstadler B, Shah H, To TL, Byrne K, Summer L, Calvo SE, Goldberger O, Doench JG, Mootha VK et al.. (2022) Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS. Nat Commun, 13 (1): 2483. [PMID:35513392]
10. Spaan AN, Ijlst L, van Roermund CW, Wijburg FA, Wanders RJ, Waterham HR. (2005) Identification of the human mitochondrial FAD transporter and its potential role in multiple acyl-CoA dehydrogenase deficiency. Mol Genet Metab, 86 (4): 441-7. [PMID:16165386]
11. Titus SA, Moran RG. (2000) Retrovirally mediated complementation of the glyB phenotype. Cloning of a human gene encoding the carrier for entry of folates into mitochondria. J Biol Chem, 275 (47): 36811-7. [PMID:10978331]
12. Wang Y, Yen FS, Zhu XG, Timson RC, Weber R, Xing C, Liu Y, Allwein B, Luo H, Yeh HW et al.. (2021) SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells. Nature, 599 (7883): 136-140. [PMID:34707288]
How to cite this family page
Database page citation:
SLC25 mitochondrial vitamin and co-factor carriers subfamily. Accessed on 11/09/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1118.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.
