The SLC3 and SLC7 families combine to generate functional transporters, where the subunit composition is a disulphide-linked combination of a heavy chain (SLC3 family) with a light chain (SLC7 family) [1].

* Key recommended reading is highlighted with an asterisk

* Bhutia YD, Babu E, Ramachandran S, Ganapathy V. (2015) Amino Acid transporters in cancer and their relevance to "glutamine addiction": novel targets for the design of a new class of anticancer drugs. Cancer Res, 75 (9): 1782-8. [PMID:25855379]

Closs EI, Boissel JP, Habermeier A, Rotmann A. (2006) Structure and function of cationic amino acid transporters (CATs). J Membr Biol, 213 (2): 67-77. [PMID:17417706]

* Fotiadis D, Kanai Y, Palacín M. (2013) The SLC3 and SLC7 families of amino acid transporters. Mol Aspects Med, 34 (2-3): 139-58. [PMID:23506863]

* Palacín M, Kanai Y. (2004) The ancillary proteins of HATs: SLC3 family of amino acid transporters. Pflugers Arch, 447 (5): 490-4. [PMID:14770309]

* Palacín M, Nunes V, Font-Llitjós M, Jiménez-Vidal M, Fort J, Gasol E, Pineda M, Feliubadaló L, Chillarón J, Zorzano A. (2005) The genetics of heteromeric amino acid transporters. Physiology (Bethesda), 20: 112-24. [PMID:15772300]

* Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y. (2004) CATs and HATs: the SLC7 family of amino acid transporters. Pflugers Arch, 447 (5): 532-42. [PMID:14770310]

1. Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL et al.. (2019) THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol, 176 Suppl 1: S397-S493. [PMID:31710713]