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ABCB subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The ABCB subfamily is composed of four full transporters and two half transporters. This is the only human subfamily to have both half and full types of transporters. ABCB1 was discovered as a protein overexpressed in certain drug resistant tumor cells. It is expressed primarily in the blood brain barrier and liver and is thought to be involved in protecting cells from toxins. Cells that overexpress this protein exhibit multi-drug resistance [1,5].

Transporters

769
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MDR1, PGP1 (ABCB1) C Show summary » More detailed page go icon to follow link

TAP1 (ABCB2) C Show summary »


Target Id 769
Systematic nomenclature ABCB2
Common abbreviation TAP1
Previous and unofficial names Antigen peptide transporter 1 | APT1 | peptide supply factor 1 (PSF-1) | peptide transporter TAP1 | RING4 | ATP-binding cassette sub-family B member 2 | Cim | Transporter 1 ABC (ATP binding cassette) | Ham1 | TAP | MTP1 | peptide transporter involved in antigen processing 1 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | transporter 1 | transporter 1, ATP binding cassette subfamily B member
Genes TAP1 (Hs), Tap1 (Mm), Tap1 (Rn)
Ensembl ID ENSG00000168394 (Hs), ENSMUSG00000037321 (Mm), ENSRNOG00000000457 (Rn)
UniProtKB AC Q03518 (Hs), P21958 (Mm), P36370 (Rn)
Comment Endoplasmic reticulum peptide transporter is a hetero-dimer composed of the two half-transporters, TAP1 (ABCB2) and TAP2 (ABCB3). The transporter shuttles peptides into the endoplasmic reticulum where they are loaded onto major histocompatibility complex class I (MHCI) molecules via the macromoldecular peptide-loading complex and are eventually presented at the cell surface, attributing to TAP an important role in the adaptive immune response [18].

TAP2 (ABCB3) C Show summary » More detailed page go icon to follow link

PGY3 (ABCB4) C Show summary »

ABCB5 C Show summary »

MTABC3 (ABCB6) C Show summary »

ABC7 (ABCB7) C Show summary »

MABC1 (ABCB8) C Show summary »

TAPL (ABCB9) C Show summary »

MTABC2 (ABCB10) C Show summary »

ABC16 (ABCB11) C Show summary »

References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.