P1B P-type ATPases: Cu<sup>+</sup>-ATPases | Transporters

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P1B P-type ATPases: Cu⁺-ATPases

P1B P-type ATPases: Cu⁺-ATPases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Copper-transporting ATPases convey copper ions across cell-surface and intracellular membranes. They consist of eight TM domains and associate with multiple copper chaperone proteins (e.g. ATOX1, O00244).

Transporters

ATP7A Show summary »« Hide summary

Target Id

852

Nomenclature

ATP7A

Previous and unofficial names

Genes

ATP7A (Hs), Atp7a (Mm), Atp7a (Rn)

Ensembl ID

ENSG00000165240 (Hs), ENSMUSG00000033792 (Mm), ENSRNOG00000002515 (Rn)

UniProtKB AC

Q04656 (Hs), Q64430 (Mm), P70705 (Rn)

EC number

3.6.3.4

ATP7B Show summary »« Hide summary

Target Id

853

Nomenclature

ATP7B

Previous and unofficial names

Genes

ATP7B (Hs), Atp7b (Mm), Atp7b (Rn)

Ensembl ID

ENSG00000123191 (Hs), ENSMUSG00000006567 (Mm), ENSRNOG00000012878 (Rn)

UniProtKB AC

P35670 (Hs), Q64446 (Mm), Q64535 (Rn)

EC number

3.6.3.4

Comment

Autosomal recessive genetic variants that decrease ATP7B function cause Wilson's disease. Symptoms arise due to excess copper accumulation and damage to organs including the liver, brain, kidneys, heart and eyes, as a direct result of inadequate ATP7B-mediated copper excretion into the biliary system.

How to cite this family page

Database page citation:

P1B P-type ATPases: Cu⁺-ATPases. Accessed on 06/10/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=161.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.

P1B P-type ATPases: Cu+-ATPases C

Overview

Transporters

How to cite this family page

P1B P-type ATPases: Cu⁺-ATPases C