Monoamine neurotransmission is limited by perisynaptic transporters. Presynaptic monoamine transporters allow recycling of synaptically released noradrenaline, dopamine and 5-hydroxytryptamine.

[¹²⁵I]RTI55 labels all three monoamine transporters (NET, DAT and SERT) with affinities between 0.5 and 5 nM. Cocaine is an inhibitor of all three transporters with pK_i values between 6.5 and 7.2. Potential alternative splicing sites in non-coding regions of SERT and NET have been identified. A bacterial homologue of SERT shows allosteric modulation by selected anti-depressants [14].

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Stefan Bröer Research School of Biology Australian National University Linnaeus Way 134 Canberra, ACT, 0200 Australia Gary Rudnick Sterling Hall of Medicine, B-Wing 333 Cedar Street, Ste B334 New Haven, CT 06510