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SLC12 family of cation-coupled chloride transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The SLC12 family of chloride transporters contribute to ion fluxes across a variety of tissues, particularly in the kidney and choroid plexus of the brain. Within this family, further subfamilies are identifiable: NKCC1, NKCC2 and NCC constitute a group of therapeutically-relevant transporters, targets for loop and thiazide diuretics. These 12 TM proteins exhibit cytoplasmic termini and an extended extracellular loop at TM7/8 and are kidney-specific (NKCC2 and NCC) or show a more widespread distribution (NKCC1). A second family, the K-Cl co-transporters are also 12 TM domain proteins with cytoplasmic termini, but with an extended extracellular loop at TM 5/6. CCC6 exhibits structural similarities with the K-Cl co-transporters, while CCC9 is divergent, with 11 TM domains and a cytoplasmic N-terminus and extracellular C-terminus.

Transporters

975
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NKCC2 (Kidney-specific Na-K-Cl symporter / SLC12A1) C Show summary » More detailed page go icon to follow link

NKCC1 (Basolateral Na-K-Cl symporter / SLC12A2) C Show summary »

NCC (Na-Cl symporter / SLC12A3) C Show summary » More detailed page go icon to follow link

KCC1 (K-Cl cotransporter 1 / SLC12A4) C Show summary »

KCC2 (K-Cl cotransporter 2 / SLC12A5) C Show summary »

KCC3 (K-Cl cotransporter 3 / SLC12A6) C Show summary »

KCC4 (K-Cl cotransporter 4 / SLC12A7) C Show summary »

CCC9 (Cation-chloride cotransporter 9 / SLC12A8) C Show summary »


Target Id 975
Nomenclature Cation-chloride cotransporter 9
Systematic nomenclature SLC12A8
Common abbreviation CCC9
Previous and unofficial names solute carrier family 12 (sodium/potassium/chloride transporters), member 8 | solute carrier family 12, member 8 | solute carrier family 12 | solute carrier family 12 (potassium/chloride transporters)
Genes SLC12A8 (Hs), Slc12a8 (Mm), Slc12a8 (Rn)
Ensembl ID ENSG00000221955 (Hs), ENSMUSG00000035506 (Mm), ENSRNOG00000001792 (Rn)
UniProtKB AC A0AV02 (Hs), Q8VI23 (Mm), Q8CJI3 (Rn)
Bioparadigms SLC Tables SLC12A8 (Hs)
Substrates
spermine
L-glutamic acid
spermidine
L-aspartic acid
Stoichiometry Unknown
Comment In mouse studies Slc12a8 has been shown to transport the nicotinamide adenine dinucleotide (NAD+) precursor, nicotinamide mononucleotide (NMN) in to cells, and administration of NMN produces anti-ageing effects in vivo [2].

CCC6 (Cation-chloride cotransporter 6 / SLC12A9) Show summary »

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Further reading

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References

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How to cite this family page

Database page citation:

SLC12 family of cation-coupled chloride transporters. Accessed on 31/07/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=184.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.