Top ▲

SLC13 family of sodium-dependent sulphate/carboxylate transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Click here for help

« Hide

Within the SLC13 family, two groups of transporters may be differentiated on the basis of the substrates transported: NaS1 and NaS2 convey sulphate, while NaC1-3 transport carboxylates. NaS1 and NaS2 transporters are made up of 13 TM domains, with an intracellular N terminus and are electrogenic with physiological roles in the intestine, kidney and placenta. NaC1, NaC2 and NaC3 are made up of 11 TM domains with an intracellular N terminus and are electrogenic, with physiological roles in the kidney and liver.

Transporters

980
Click here for help

NaS1 (Na+/sulfate cotransporter / SLC13A1) C Show summary »

NaC1 (Na+/dicarboxylate cotransporter 1 / SLC13A2) C Show summary »

NaC3 (Na+/dicarboxylate cotransporter 3 / SLC13A3) C Show summary »

NaS2 (Na+/sulfate cotransporter / SLC13A4) C Show summary »


Target Id 980
Nomenclature Na+/sulfate cotransporter
Systematic nomenclature SLC13A4
Common abbreviation NaS2
Previous and unofficial names SUT1 | sulphate transporter 1 | sodium sulfate cotransporter-2 | solute carrier family 13 (sodium/sulfate symporters), member 4 | solute carrier family 13 (sodium/sulfate symporter), member 4 | solute carrier family 13 (sodium/sulfate symporters)
Genes SLC13A4 (Hs), Slc13a4 (Mm), Slc13a4 (Rn)
Ensembl ID ENSG00000164707 (Hs), ENSMUSG00000029843 (Mm), ENSRNOG00000011184 (Rn)
UniProtKB AC Q9UKG4 (Hs)
Bioparadigms SLC Tables SLC13A4 (Hs)
Endogenous substrates
SO42-
Stoichiometry 3 Na+ : SO42- (in)

NaC2 (Na+/citrate cotransporter / SLC13A5) C Show summary »

Further reading

Click here for help

Show »

References

Click here for help

Show »

How to cite this family page

Database page citation:

SLC13 family of sodium-dependent sulphate/carboxylate transporters. Accessed on 17/09/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=185.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.