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SLC13 family of sodium-dependent sulphate/carboxylate transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Within the SLC13 family, two groups of transporters may be differentiated on the basis of the substrates transported: NaS1 and NaS2 convey sulphate, while NaC1-3 transport carboxylates. NaS1 and NaS2 transporters are made up of 13 TM domains, with an intracellular N terminus and are electrogenic with physiological roles in the intestine, kidney and placenta. NaC1, NaC2 and NaC3 are made up of 11 TM domains with an intracellular N terminus and are electrogenic, with physiological roles in the kidney and liver.

Transporters

981
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NaS1 (Na+/sulfate cotransporter / SLC13A1) C Show summary »

NaC1 (Na+/dicarboxylate cotransporter 1 / SLC13A2) C Show summary »

NaC3 (Na+/dicarboxylate cotransporter 3 / SLC13A3) C Show summary »

NaS2 (Na+/sulfate cotransporter / SLC13A4) C Show summary »

NaC2 (Na+/citrate cotransporter / SLC13A5) C Show summary »


Target Id 981
Nomenclature Na+/citrate cotransporter
Systematic nomenclature SLC13A5
Common abbreviation NaC2
Previous and unofficial names NaCT | Sodium-coupled citrate transporter | sodium-dependent citrate transporter | solute carrier family 13 member 5 | Indy | solute carrier family 13 (sodium-dependent citrate transporter), member 5 | solute carrier family 13 (sodium-dependent citrate transporter)
Genes SLC13A5 (Hs), Slc13a5 (Mm), Slc13a5 (Rn)
Ensembl ID ENSG00000141485 (Hs), ENSMUSG00000020805 (Mm), ENSRNOG00000014870 (Rn)
UniProtKB AC Q86YT5 (Hs), Q67BT3 (Mm), Q8CJ44 (Rn)
Bioparadigms SLC Tables SLC13A5 (Hs)
Endogenous substrates
citric acid
pyruvic acid
Selective inhibitors
BI01383298 pIC50 7.3 [1]
Stoichiometry Unknown
Comment Expressed in hepatocytes where it is involved in the synthesis of sterols and faty acids. Potential drug target for obesity and diabetes.

Further reading

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References

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How to cite this family page

Database page citation:

SLC13 family of sodium-dependent sulphate/carboxylate transporters. Accessed on 26/07/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=185.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.