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Organic cation transporters (OCT) C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Organic cation transporters (OCT) are electrogenic, Na+-independent and reversible.

Transporters

1021
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OCT1 (Organic cation transporter 1 / SLC22A1) C Show summary »

OCT2 (Organic cation transporter 2 / SLC22A2) C Show summary » More detailed page go icon to follow link

OCT3 (Organic cation transporter 3 / SLC22A3) C Show summary »


Target Id 1021
Nomenclature Organic cation transporter 3
Systematic nomenclature SLC22A3
Common abbreviation OCT3
Previous and unofficial names EMT | Extraneuronal monoamine transporter | organic cation transporter 3 | solute carrier family 22 (organic cation transporter), member 3 | Orct3 | solute carrier family 22 (extraneuronal monoamine transporter), member 3 | solute carrier family 22 (organic cation transporter)
Genes SLC22A3 (Hs), Slc22a3 (Mm), Slc22a3 (Rn)
Ensembl ID ENSG00000146477 (Hs), ENSMUSG00000023828 (Mm), ENSRNOG00000022946 (Rn)
UniProtKB AC O75751 (Hs), Q9WTW5 (Mm), O88446 (Rn)
Bioparadigms SLC Tables SLC22A3 (Hs)
Endogenous substrates
5-hydroxytryptamine [8]
(-)-noradrenaline [8]
dopamine [8]
Substrates
quinidine
tetraethylammonium
MPP+
metformin [5]
Inhibitors
disprocynium24 pKi 7.8 [3]
Stoichiometry Unknown

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Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.