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SLC24 family of sodium/potassium/calcium exchangers C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The sodium/potassium/calcium exchange family of transporters utilize the extracellular sodium gradient to drive calcium and potassium co-transport out of the cell. As is the case for NCX transporters (SLC8A family), NKCX transporters are thought to be bidirectional, with the possibility of calcium influx following depolarization of the plasma membrane. Topological modeling suggests the presence of 10 TM domains, with a large intracellular loop between the fifth and sixth TM regions.

Transporters

1045
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NKCX1 (Sodium/potassium/calcium exchanger 1 / SLC24A1) C Show summary »


Target Id 1045
Nomenclature Sodium/potassium/calcium exchanger 1
Systematic nomenclature SLC24A1
Common abbreviation NKCX1
Previous and unofficial names Retinal rod Na-Ca+K exchanger | NCKX | NCKX1 | RODX | retinal Na/Ca,K exchanger | solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 | solute carrier family 24 (sodium/potassium/calcium exchanger)
Genes SLC24A1 (Hs), Slc24a1 (Mm), Slc24a1 (Rn)
Ensembl ID ENSG00000074621 (Hs), ENSMUSG00000034452 (Mm), ENSRNOG00000026904 (Rn)
UniProtKB AC O60721 (Hs), Q9QZM6 (Rn)
Bioparadigms SLC Tables SLC24A1 (Hs)
Stoichiometry 4Na+:(1Ca2+ + 1K+)

NKCX2 (Sodium/potassium/calcium exchanger 2 / SLC24A2) Show summary »

NKCX3 (Sodium/potassium/calcium exchanger 3 / SLC24A3) Show summary »

NKCX4 (Sodium/potassium/calcium exchanger 4 / SLC24A4) Show summary » More detailed page go icon to follow link

NKCX5 (Sodium/potassium/calcium exchanger 5 / SLC24A5) Show summary »

NKCX6 (Sodium/potassium/calcium exchanger 6 / SLC24A6) C Show summary »

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References

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How to cite this family page

Database page citation:

SLC24 family of sodium/potassium/calcium exchangers. Accessed on 31/07/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=202.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.