Mitochondrial di- and tri-carboxylic acid transporter subfamily | Transporters

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Mitochondrial di- and tri-carboxylic acid transporter subfamily

Mitochondrial di- and tri-carboxylic acid transporter subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Mitochondrial di- and tri-carboxylic acid transporters are grouped on the basis of commonality of substrates and include the citrate transporter which facilitates citric acid export from the mitochondria to allow the generation of oxalacetic acid and acetyl CoA through the action of ATP:citrate lyase.

Transporters

CIC (Mitochondrial citrate transporter / SLC25A1) C Show summary »« Hide summary

Target Id

1051

Nomenclature

Mitochondrial citrate transporter

Systematic nomenclature

SLC25A1

Common abbreviation

CIC

Previous and unofficial names

citrate isocitrate carrier | Citrate transport protein | CTP | SLC20A3 | solute carrier family 20 (mitochondrial citrate transporter), member 3 | mitochondrial tricarboxylate carrier | solute carrier family 25 (mitochondrial carrier; citrate transporter) member 1 | Dgsj | solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 | solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1 | solute carrier family 25 (mitochondrial carrier

Genes

SLC25A1 (Hs), Slc25a1 (Mm), Slc25a1 (Rn)

Ensembl ID

ENSG00000100075 (Hs), ENSMUSG00000003528 (Mm), ENSRNOG00000038001 (Rn)

UniProtKB AC

P53007 (Hs), P32089 (Rn)

Bioparadigms SLC Tables

SLC25A1 (Hs)

RESOLUTE

SLC25A1 (Hs)

Substrates

citric acid

malic acid

phosphoenolpyruvic acid

Inhibitors

CTPI-2 pK_d 5.5 [1]

1,2,3-benzenetricarboxylic acid

Stoichiometry

Malate^2- (in) : H-citrate^2- (out)

Comment

A potential clinical target for modulating cytosolic citrate and disordered lipid metabolism related to metabolic diseases [2].

DIC (Mitochondrial dicarboxylate transporter / SLC25A10) C Show summary »« Hide summary

Target Id

1052

Nomenclature

Mitochondrial dicarboxylate transporter

Systematic nomenclature

SLC25A10

Common abbreviation

DIC

Previous and unofficial names

DIC1 | mitochondrial dicarboxylate carrier | solute carrier family 25 (mitochondrial carrier; decarboxylate transporter), member 10 | solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 | solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10 | solute carrier family 25 (mitochondrial carrier

Genes

SLC25A10 (Hs), Slc25a10 (Mm), Slc25a10 (Rn)

Ensembl ID

ENSG00000183048 (Hs), ENSMUSG00000025792 (Mm), ENSRNOG00000036693 (Rn)

UniProtKB AC

Q9UBX3 (Hs), Q9QZD8 (Mm)

Bioparadigms SLC Tables

SLC25A10 (Hs)

RESOLUTE

SLC25A10 (Hs)

Substrates

malic acid

succinic acid

phosphate

SO₄^2-

S₂O₃^2-

Stoichiometry

PO₃^4- (in) : malate^2- (out)

OGC (Mitochondrial oxoglutarate carrier / SLC25A11) C Show summary »« Hide summary

Target Id

1053

Nomenclature

Mitochondrial oxoglutarate carrier

Systematic nomenclature

SLC25A11

Common abbreviation

OGC

Previous and unofficial names

Genes

SLC25A11 (Hs), Slc25a11 (Mm), Slc25a11 (Rn)

Ensembl ID

ENSG00000108528 (Hs), ENSMUSG00000014606 (Mm), ENSRNOG00000003815 (Rn)

UniProtKB AC

Q02978 (Hs), Q9CR62 (Mm), P97700 (Rn)

Bioparadigms SLC Tables

SLC25A11 (Hs)

RESOLUTE

SLC25A11 (Hs)

Substrates

malic acid

α-ketoglutaric acid

Stoichiometry

Malate^2- (in) : oxoglutarate^2- (out)

ODC (Mitochondrial oxodicarboxylate carrier / SLC25A21) C Show summary »« Hide summary

Target Id

1057

Nomenclature

Mitochondrial oxodicarboxylate carrier

Systematic nomenclature

SLC25A21

Common abbreviation

ODC

Previous and unofficial names

Genes

SLC25A21 (Hs), Slc25a21 (Mm), Slc25a21 (Rn)

Ensembl ID

ENSG00000183032 (Hs), ENSMUSG00000035472 (Mm), ENSRNOG00000008931 (Rn)

UniProtKB AC

Q9BQT8 (Hs), Q8BZ09 (Mm), Q99JD3 (Rn)

Bioparadigms SLC Tables

SLC25A21 (Hs)

RESOLUTE

SLC25A21 (Hs)

Substrates

α-ketoglutaric acid

α-oxoadipic acid

Stoichiometry

Oxoadipate (in) : oxoglutarate (out)

SLC25A34 Show summary »« Hide summary

SLC25A35 Show summary »« Hide summary

References

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How to cite this family page

Database page citation:

Mitochondrial di- and tri-carboxylic acid transporter subfamily. Accessed on 16/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=203.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.