Mitochondrial phosphate transporters | Transporters | IUPHAR/BPS Guide to PHARMACOLOGY

From August 18th 2026, GtoPdb will require users to register to use the website. Please see our blog post for more information.

Home
Targets
Transporters
SLC superfamily of solute carriers
SLC25 family of mitochondrial transporters
Mitochondrial phosphate transporters

Mitochondrial phosphate transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Show »« Hide

Mitochondrial phosphate transporters allow the import of inorganic phosphate for ATP production.

Transporters

PHC (Mitochondrial phosphate carrier / SLC25A3) C Show summary »« Hide summary

Target Id	1061
Nomenclature	Mitochondrial phosphate carrier
Systematic nomenclature	SLC25A3
Common abbreviation	PHC
Previous and unofficial names	PiC \| PTP \| solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 3 \| solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 \| solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 \| solute carrier family 25 (mitochondrial carrier
Genes	SLC25A3 (Hs), Slc25a3 (Mm), Slc25a3 (Rn)
Ensembl ID	ENSG00000075415 (Hs), ENSMUSG00000061904 (Mm), ENSRNOG00000008797 (Rn)
UniProtKB AC	Q00325 (Hs), Q8VEM8 (Mm), P16036 (Rn)
Bioparadigms SLC Tables	SLC25A3 (Hs)
RESOLUTE	SLC25A3 (Hs)
Stoichiometry	PO₃^4- (in) : OH^- (out) or PO₃^4- : H⁺ (in)
Comment	Mutations cause mitochondrial phosphate carrier deficiency [1].

References

Show »« Hide

How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Transporters. Br J Pharmacol. 182: S404-S496.