Top ▲

Mitochondrial nucleotide transporter subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Click here for help

« Hide

Mitochondrial nucleotide transporters, defined by structural similarlities, include the adenine nucleotide translocator family (SLC25A4, SLC25A5, SLC25A6 and SLC25A31), which under conditions of aerobic metabolism, allow coupling between mitochondrial oxidative phosphorylation and cytosolic energy consumption by exchanging cytosolic ADP for mitochondrial ATP. Further members of the mitochondrial nucleotide transporter subfamily convey diverse substrates including CoA, although not all members have had substrates identified.

Transporters

1062
Click here for help

ANT1 (Mitochondrial adenine nucleotide translocator 1 / SLC25A4) C Show summary »


Target Id 1062
Nomenclature Mitochondrial adenine nucleotide translocator 1
Systematic nomenclature SLC25A4
Common abbreviation ANT1
Previous and unofficial names ADP,ATP carrier protein 1 | ADP,ATP carrier protein, heart/skeletal muscle isoform T1 | PEO2 | PEO3 | T1 | ADP/ATP translocase 1 | solute carrier family 25 (mitochondrial adenine nucleotide translocator) member 4 | adenine nucleotide translocase-1 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 | solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 | solute carrier family 25 (mitochondrial carrier
Genes SLC25A4 (Hs), Slc25a4 (Mm), Slc25a4 (Rn)
Ensembl ID ENSG00000151729 (Hs), ENSMUSG00000031633 (Mm), ENSRNOG00000010830 (Rn)
UniProtKB AC P12235 (Hs), P48962 (Mm), Q05962 (Rn)
Bioparadigms SLC Tables SLC25A4 (Hs)
Inhibitors
carboxyatractyloside
bongkrek acid
Stoichiometry ADP3- (in) : ATP4- (out)

ANT2 (Mitochondrial adenine nucleotide translocator 2 / SLC25A5) C Show summary »

ANT3 (Mitochondrial adenine nucleotide translocator 3 / SLC25A6) C Show summary »

ANT4 (Mitochondrial adenine nucleotide translocator 4 / SLC25A31) C Show summary »

GDC (Graves disease carrier / SLC25A16) C Show summary »

PMP34 (Peroxisomal membrane protein / SLC25A17) C Show summary »

DNC (Deoxynucleotide carrier 1 / SLC25A19) C Show summary »

SAMC1 (S-Adenosylmethionine carrier / SLC25A26) C Show summary »

SLC25A42 Show summary »

APC1 (Mitochondrial phosphate carrier 1 / SLC25A24) C Show summary »

APC2 (Mitochondrial phosphate carrier 2 / SLC25A23) C Show summary »

APC3 (Mitochondrial phosphate carrier 3 / SLC25A25) C Show summary »

MFTC (MFT / SLC25A32) Show summary »

PNC1 / SLC25A33 Show summary »

PNC2 (SLC25A36) Show summary »

SCaMC-3L / SLC25A41 Show summary »

SLC25A43 Show summary »

How to cite this family page

Database page citation:

Mitochondrial nucleotide transporter subfamily. Accessed on 23/07/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=206.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.