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SLC29 family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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SLC29 family members are composed of 11 TM segments with cytoplasmic N-termini and extracellular C-termini. ENT1, ENT2 and ENT4 are primarily cell-surface transporters, while ENT3 is intracellular, possibly lysosomal [2]]. ENT2 isoforms may also play a role in the nucleolar transport of nucleosides [9]. ENT1-3 are described as broad-spectrum equilibrative nucleoside transporters. ENT4 is primarily a polyspecific organic cation transporter at neutral pH [12], but transports adenosine and analogues such as 2-chloroadenosine, with affinities similar to other members of the SLC29 family, at acidic pH [17].

Transporters

1120
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ENT1 (Equilibrative nucleoside transporter 1 / SLC29A1) C Show summary »

ENT2 (Equilibrative nucleoside transporter 2 / SLC29A2) C Show summary »

ENT3 (Equilibrative nucleoside transporter 3 / SLC29A3) C Show summary »

PMAT (Plasma membrane monoamine transporter / SLC29A4) C Show summary »


Target Id 1120
Nomenclature Plasma membrane monoamine transporter
Systematic nomenclature SLC29A4
Common abbreviation PMAT
Previous and unofficial names ENT4 | solute carrier family 29 (nucleoside transporters), member 4 | Equilibrative nucleoside transporter 4 | solute carrier family 29 (equilibrative nucleoside transporter), member 4 | solute carrier family 29 (nucleoside transporters)
Genes SLC29A4 (Hs), Slc29a4 (Mm), Slc29a4 (Rn)
Ensembl ID ENSG00000164638 (Hs), ENSMUSG00000050822 (Mm), ENSRNOG00000001115 (Rn)
UniProtKB AC Q7RTT9 (Hs), Q8R139 (Mm)
Bioparadigms SLC Tables SLC29A4 (Hs)
Endogenous substrates
5-hydroxytryptamine [7,19]
dopamine [7,19]
histamine [7,19]
tyramine [7,19]
adenosine [23]
Substrates
atenolol [15]
tetraethylammonium [7,19]
MPP+ [7,19]
metformin [24]
Inhibitors
decynium 22 pKi 7.0 [7,19]
rhodamine123 pKi 6.0 [7,19]
dipyridamole pKi 5.9 [18]
verapamil pKi 4.7 [7,19]
fluoxetine pKi 4.6 [7,19]
quinidine pKi 4.6 [7,19]
quinine pKi 4.6 [7,19]
desipramine pKi 4.5 [7,19]
cimetidine pKi <3.3 [7,19]
Stoichiometry Equilibrative
Comment Uptake of substrates by PMAT is pH dependent, with greater uptake observed at acidic extracellular pH [3,24].

Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.