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SLCO family of organic anion transporting polypeptides C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The SLCO superfamily is comprised of the organic anion transporting polypeptides (OATPs). The 11 human OATPs are divided into 6 families and ten subfamilies based on amino acid identity. These proteins are located on the plasma membrane of cells throughout the body. They have 12 TM domains and intracellular termini, with multiple putative glycosylation sites. OATPs mediate the sodium-independent uptake of a wide range of amphiphilic substrates, including many drugs and toxins. Due to the multispecificity of these proteins, this guide lists classes of substrates and inhibitors for each family member. More comprehensive lists of substrates, inhibitors, and their relative affinities may be found in the review articles listed below.

Transporters

1226
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OATP1A2 / SLCO1A2 C Show summary »

OATP1B1 / SLCO1B1 C Show summary »

OATP1B3 / SLCO1B3 C Show summary »

OATP1C1 / SLCO1C1 C Show summary »

OATP2A1 / SLCO2A1 C Show summary »

OATP2B1 / SLCO2B1 C Show summary »

OATP3A1 / SLCO3A1 C Show summary »

OATP4A1 / SLCO4A1 C Show summary »


Target Id 1226
Nomenclature OATP4A1
Systematic nomenclature SLCO4A1
Previous and unofficial names OATP-E | SLC21A12 | solute carrier family 21 (organic anion transporter), member 12 | organic anion-transporting polypeptide E | sodium-independent organic anion transporter E | solute carrier organic anion transporter family member 4A1 | solute carrier organic anion transporter family, member 4A1 | solute carrier organic anion transporter family
Genes SLCO4A1 (Hs), Slco4a1 (Mm), Slco4a1 (Rn)
Ensembl ID ENSG00000101187 (Hs), ENSMUSG00000038963 (Mm), ENSRNOG00000021870 (Rn)
UniProtKB AC Q96BD0 (Hs), Q8K078 (Mm), Q99N01 (Rn)
Endogenous substrates
bile acids
prostaglandins
steroid conjugates
thyroid hormones
Substrates
penicillin G
Labelled ligands
[3H]estrone-3-sulphate

OATP4C1 / SLCO4C1 C Show summary »

OATP5A1 / SLCO5A1 Show summary »

OATP6A1 / SLCO6A1 Show summary »

Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.