Arginine:glycine amidinotransferase | Enzymes | IUPHAR/BPS Guide to PHARMACOLOGY

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L-Arginine turnover
Arginine:glycine amidinotransferase

Arginine:glycine amidinotransferase C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Arginine:glycine amidinotransferase is a mitochondrial enzyme that is involved in creatine biosynthesis.

Enzymes

AGAT (Arginine:glycine amidinotransferase) C Show summary »« Hide summary

Target Id

1246

Nomenclature

Arginine:glycine amidinotransferase

Common abbreviation

AGAT

Previous and unofficial names

GATM | AT | glycine amidinotransferase, mitochondrial | transamidinase | glycine amidinotransferase (L-arginine:glycine amidinotransferase)

Genes

GATM (Hs), Gatm (Mm), Gatm (Rn)

Ensembl ID

ENSG00000171766 (Hs), ENSMUSG00000027199 (Mm), ENSRNOG00000000168 (Rn)

UniProtKB AC

P50440 (Hs), Q9D964 (Mm), P50442 (Rn)

EC number

2.1.4.1

Comments

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How to cite this family page

Database page citation:

Arginine:glycine amidinotransferase. Accessed on 15/04/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=251.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Enzymes. Br J Pharmacol. 182: S307-S403.