CYP39, CYP46 and CYP51 families | Enzymes | IUPHAR/BPS Guide to PHARMACOLOGY

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Cytochrome P450
CYP39, CYP46 and CYP51 families

CYP39, CYP46 and CYP51 families C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

CYP39A1 C Show summary »« Hide summary

Target Id

1372

Nomenclature

CYP39A1

Previous and unofficial names

24-hydroxycholesterol 7-alpha-hydroxylase | oxysterol 7-alpha-hydroxylase | cytochrome P450, family 39, subfamily A, polypeptide 1 | cytochrome P450

Genes

CYP39A1 (Hs), Cyp39a1 (Mm), Cyp39a1 (Rn)

Ensembl ID

ENSG00000146233 (Hs), ENSMUSG00000023963 (Mm), ENSRNOG00000010519 (Rn)

UniProtKB AC

Q9NYL5 (Hs), Q9JKJ9 (Mm)

EC number

1.14.13.99

Comment

Converts 24-hydroxycholesterol to 7α,24-dihydroxycholesterol [1].

Cholesterol 24-hydroxylase (CYP46A1) C Show summary »« Hide summary

Lanosterol 14-α-demethylase (CYP51A1) C Show summary »« Hide summary

Target Id

1374

Nomenclature

CYP51A1

Common abbreviation

Lanosterol 14-α-demethylase

Previous and unofficial names

lanosterol 14-alpha demethylase | sterol 14-alpha demethylase | Cytochrom P450 Lanosterol 14 alpha-demethylase | cytochrome P450, family 51, subfamily A, polypeptide 1 | cytochrome P450

Genes

CYP51A1 (Hs), Cyp51 (Mm), Cyp51 (Rn)

Ensembl ID

ENSG00000001630 (Hs), ENSMUSG00000001467 (Mm), ENSRNOG00000007234 (Rn)

UniProtKB AC

Q16850 (Hs), Q8K0C4 (Mm), Q64654 (Rn)

Inhibitors

azalanstat pK_i 9.1 [2]

Comment

Converts lanosterol to 4,4-dimethylcholesta-8.14.24-trienol.

References

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How to cite this family page

Database page citation:

CYP39, CYP46 and CYP51 families. Accessed on 23/02/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=268.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.