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Prostaglandin synthases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Subsequent to the formation of PGH2, the cytochrome P450 activities thromboxane synthase (CYP5A1, TBXAS1, P24557 , EC 5.3.99.5) and prostacyclin synthase (CYP8A1, PTGIS, Q16647, EC 5.3.99.4) generate thromboxane A2 and prostacyclin (PGI2), respectively. Additionally, multiple enzyme activities are able to generate prostaglandin E2 (PGE2), prostaglandin D2 (PGD2) and prostaglandin F (PGF). PGD2 can be metabolised to 9α,11β-prostacyclin F through the multifunctional enzyme activity of AKR1C3. PGE2 can be metabolised to 9α,11β-prostaglandin F through the 9-ketoreductase activity of CBR1. Conversion of the 15-hydroxyecosanoids, including prostaglandins, lipoxins and leukotrienes to their keto derivatives by the NAD-dependent enzyme HPGD leads to a reduction in their biological activity.

Enzymes

1379
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Thromboxane-A synthase (CYP5A1) C Show summary » More detailed page go icon to follow link

Prostacyclin synthase (CYP8A1) C Show summary »

mPGES1 C Show summary » More detailed page go icon to follow link

mPGES2 C Show summary »

cPGES C Show summary »


Target Id 1379
Nomenclature cPGES
Previous and unofficial names Cytosolic prostaglandin E2 synthase | prostaglandin E synthase 3 | telomerase-binding protein p23 | TEBP | prostaglandin E synthase 3 (cytosolic)
Genes PTGES3 (Hs), Ptges3 (Mm), Ptges3 (Rn)
Ensembl ID ENSG00000110958 (Hs), ENSMUSG00000071072 (Mm), ENSRNOG00000002642 (Rn)
UniProtKB AC Q15185 (Hs), Q9R0Q7 (Mm), P83868 (Rn)
EC number
5.3.99.3 PGH2 = PGE2
Comment Phosphorylated and activated by casein kinase 2 (CK2) [14].
Appears to regulate steroid hormone function by interaction with dimeric hsp90 [2,13].

L-PGDS C Show summary »

H-PGDS C Show summary »

AKR1C3 C Show summary » More detailed page go icon to follow link

CBR1 C Show summary »

HPGD C Show summary » More detailed page go icon to follow link

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.