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Inositol 1,4,5-trisphosphate 3-kinases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Inositol 1,4,5-trisphosphate 3-kinases (E.C. 2.7.1.127, ENSFM00250000001260) catalyse the generation of inositol 1,3,4,5-tetrakisphosphate (IP4) from IP3. IP3 kinase activity is enhanced in the presence of calcium/calmodulin (CALM2, CALM3, CALM1, P62158) [1].

Enzymes

1447
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IP3 kinase A Show summary »

Target Id 1447
Nomenclature IP3 kinase A
Previous and unofficial names IP3KA | inositol 1,4,5-trisphosphate 3-kinase A | insP 3-kinase A | IP3 3-kinase A | IP3-kinase A | inositol 1
Genes ITPKA (Hs), Itpka (Mm), Itpka (Rn)
Ensembl ID ENSG00000137825 (Hs), ENSMUSG00000027296 (Mm), ENSRNOG00000005284 (Rn)
UniProtKB AC P23677 (Hs), Q8R071 (Mm), P17105 (Rn)
EC number
2.7.1.127
Inhibitors
GNF362 pIC50 7.7 [2]

IP3 kinase B Show summary » More detailed page go icon to follow link

IP3 kinase C Show summary »

References

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How to cite this family page

Database page citation:

Inositol 1,4,5-trisphosphate 3-kinases. Accessed on 19/03/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=280.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.