Inositol polyphosphate phosphatases | Enzymes | IUPHAR/BPS Guide to PHARMACOLOGY

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Inositol phosphate turnover
Inositol polyphosphate phosphatases

Inositol polyphosphate phosphatases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Members of this family exhibit phosphatase activity towards IP₃, as well as towards other inositol derivatives, including the phospholipids PIP₂ and PIP₃. With IP₃ as substrate, 1-phosphatase (EC 3.1.3.57) generates 4,5,-IP₂, 4-phosphatases (EC 3.1.3.66, ENSFM00250000001432) generate 1,5,-IP₂ and 5-phosphatases (E.C. 3.1.3.36 or 3.1.3.56) generate 1,4,-IP₂.

Enzymes

1452

INPP1 Show summary »« Hide summary

INPP4A Show summary »« Hide summary

Target Id

1451

Nomenclature

INPP4A

Previous and unofficial names

Genes

INPP4A (Hs), Inpp4a (Mm), Inpp4a (Rn)

Ensembl ID

ENSG00000040933 (Hs), ENSMUSG00000026113 (Mm), ENSRNOG00000017660 (Rn)

UniProtKB AC

Q96PE3 (Hs), Q9EPW0 (Mm), Q62784 (Rn)

EC number

3.1.3.36

INPP4B Show summary »« Hide summary

Target Id

1452

Nomenclature

INPP4B

Previous and unofficial names

105 kDa INPP4 | inositol polyphosphate-4-phosphatase type II 105kD | type II inositol 3,4-bisphosphate 4-phosphatase | inositol polyphosphate-4-phosphatase, type II, 105kDa | inositol polyphosphate-4-phosphatase

Genes

INPP4B (Hs), Inpp4b (Mm), Inpp4b (Rn)

Ensembl ID

ENSG00000109452 (Hs), ENSMUSG00000037940 (Mm), ENSRNOG00000018382 (Rn)

UniProtKB AC

O15327 (Hs), Q6P1Y8 (Mm), Q9QWG5 (Rn)

EC number

3.1.3.36

INPP5A Show summary »« Hide summary

Target Id

1453

Nomenclature

INPP5A

Previous and unofficial names

Genes

INPP5A (Hs), Inpp5a (Mm), Inpp5a (Rn)

Ensembl ID

ENSG00000068383 (Hs), ENSMUSG00000025477 (Mm), ENSRNOG00000017635 (Rn)

UniProtKB AC

Q14642 (Hs)

EC number

3.1.3.56

Inhibitors

compound 5 [Noble et al., 1992] pK_i 5.9 [2]

INPP5B Show summary »« Hide summary

Target Id

1454

Nomenclature

INPP5B

Previous and unofficial names

inositol polyphosphate-5-phosphatase, 75kD | inositol polyphosphate-5-phosphatase B | inositol polyphosphate-5-phosphatase, 75kDa

Genes

INPP5B (Hs), Inpp5b (Mm), Inpp5b (Rn)

Ensembl ID

ENSG00000204084 (Hs), ENSMUSG00000028894 (Mm), ENSRNOG00000048506 (Rn)

UniProtKB AC

P32019 (Hs), Q8K337 (Mm)

EC number

3.1.3.56

SHIP1 (INPP5D) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1455

Nomenclature

INPP5D

Common abbreviation

SHIP1

Previous and unofficial names

Inositol polyphosphate-5-phosphatase 145 kDa | inositol polyphosphate-5-phosphatase D | phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 | SH2 domain-containing inositol 5'-phosphatase 1 | Src homology 2 domain-containing inositol-5-phosphatase | inositol polyphosphate-5-phosphatase, 145kDa

Genes

INPP5D (Hs), Inpp5d (Mm), Inpp5d (Rn)

Ensembl ID

ENSG00000168918 (Hs), ENSMUSG00000026288 (Mm), ENSRNOG00000017020 (Rn)

UniProtKB AC

Q92835 (Hs), Q9ES52 (Mm), P97573 (Rn)

EC number

3.1.3.86
Hydrolysis of the 5' phosphate of phosphatidylinositol (PtdIns) trisphosphate to PtdIns 3,4 biphosphate 1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H(2)O <=>> 1-phosphatidyl-1D-myo-inositol 3,4-diphosphate + phosphate

Activators

rosiptor [4]

Selective inhibitors

3 alpha-aminocholestane [1]

INPP5E Show summary »« Hide summary

Target Id

1456

Nomenclature

INPP5E

Previous and unofficial names

Genes

INPP5E (Hs), Inpp5e (Mm), Inpp5e (Rn)

Ensembl ID

ENSG00000148384 (Hs), ENSMUSG00000026925 (Mm), ENSRNOG00000019039 (Rn)

UniProtKB AC

Q9NRR6 (Hs), Q9JII1 (Mm), Q9WVR1 (Rn)

EC number

3.1.3.36

INPP5J Show summary »« Hide summary

Target Id

1457

Nomenclature

INPP5J

Previous and unofficial names

Genes

INPP5J (Hs), Inpp5j (Mm), Inpp5j (Rn)

Ensembl ID

ENSG00000185133 (Hs), ENSMUSG00000034570 (Mm), ENSRNOG00000019361 (Rn)

UniProtKB AC

Q15735 (Hs), P59644 (Mm), Q9JMC1 (Rn)

EC number

3.1.3.56

INPP5K Show summary »« Hide summary

INPPL1 Show summary »« Hide summary

Target Id

1459

Nomenclature

INPPL1

Previous and unofficial names

Genes

INPPL1 (Hs), Inppl1 (Mm), Inppl1 (Rn)

Ensembl ID

ENSG00000165458 (Hs), ENSMUSG00000032737 (Mm), ENSRNOG00000019730 (Rn)

UniProtKB AC

O15357 (Hs), Q6P549 (Mm), Q9WVR3 (Rn)

EC number

3.1.3.86

Inhibitors

AS1949490 pIC₅₀ 6.2 [5]

OCRL Show summary »« Hide summary

Target Id

1460

Nomenclature

OCRL

Previous and unofficial names

OCSL | Oculocerebrorenal syndrome of Lowe | oculocerebrorenal syndrome of Lowe | OCRL, inositol polyphosphate-5-phosphatase

Genes

OCRL (Hs), Ocrl (Mm), Ocrl (Rn)

Ensembl ID

ENSG00000122126 (Hs), ENSMUSG00000001173 (Mm), ENSRNOG00000003875 (Rn)

UniProtKB AC

Q01968 (Hs), Q6NVF0 (Mm), D3ZGS3 (Rn)

EC number

3.1.3.36

SYNJ1 Show summary »« Hide summary

SYNJ2 Show summary »« Hide summary

Comments

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References

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1. Brooks R, Fuhler GM, Iyer S, Smith MJ, Park MY, Paraiso KH, Engelman RW, Kerr WG. (2010) SHIP1 inhibition increases immunoregulatory capacity and triggers apoptosis of hematopoietic cancer cells. J Immunol, 184 (7): 3582-9. [PMID:20200281]

2. Noble NJ, Dubreuil D, Potter BVL. (1992) Total synthesis of myo-inositol-1-phosphate-4,5-pyrophosphate, a novel second messenger analogue, via myo-inositol-1-phosphate-4,5-bisphosphorothioate. Bioorg Med Chem Lett, 2 (5): 471-476.

3. Schmid AC, Wise HM, Mitchell CA, Nussbaum R, Woscholski R. (2004) Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation. FEBS Lett, 576 (1-2): 9-13. [PMID:15474001]

4. Stenton GR, Mackenzie LF, Tam P, Cross JL, Harwig C, Raymond J, Toews J, Wu J, Ogden N, MacRury T et al.. (2013) Characterization of AQX-1125, a small-molecule SHIP1 activator: Part 1. Effects on inflammatory cell activation and chemotaxis in vitro and pharmacokinetic characterization in vivo. Br J Pharmacol, 168 (6): 1506-18. [PMID:23121445]

5. Suwa A, Yamamoto T, Sawada A, Minoura K, Hosogai N, Tahara A, Kurama T, Shimokawa T, Aramori I. (2009) Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2. Br J Pharmacol, 158 (3): 879-87. [PMID:19694723]

How to cite this family page

Database page citation:

Inositol polyphosphate phosphatases. Accessed on 02/04/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=281.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Enzymes. Br J Pharmacol. 182: S307-S403.