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Protein kinase A (PKA) family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Cyclic AMP-mediated signalling involves regulation of cyclic nucleotide-gated ion channels, members of the Rap guanine nucleotide exchange family (Epac, ENSFM00250000000899) and activation of protein kinase A (PKA, also known as cyclic AMP-dependent protein kinase). PKA is a heterotetrameric enzyme composed of two regulatory and two catalytic subunits, which can be distinguished from Epac (exchange protein directly activated by cyclic AMP, [2]) by differential activation by N6 benzyl-cAMP (see Table) and 8-pCPT-2'-O-Me-cAMP, respectively [3].

Enzymes

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Complexes

protein kinase A Show summary » More detailed page go icon to follow link

Enzymes and Subunits

PKAR1A (protein kinase, cAMP-dependent, regulatory, type I, alpha subunit) Show summary » More detailed page go icon to follow link

PRKAR1B (protein kinase, cAMP-dependent, regulatory, type I, beta subunit) Show summary » More detailed page go icon to follow link

PRKAR2A (protein kinase, cAMP-dependent, regulatory, type II, alpha subunit) Show summary » More detailed page go icon to follow link

PKAR2B (protein kinase, cAMP-dependent, regulatory, type II, beta subunit) Show summary » More detailed page go icon to follow link

PKACa (protein kinase, cAMP-dependent, catalytic, alpha subunit) Show summary » More detailed page go icon to follow link

PKACb (protein kinase, cAMP-dependent, catalytic, beta subunit) Show summary » More detailed page go icon to follow link

PKACg (protein kinase, cAMP-dependent, catalytic, gamma subunit) Show summary » More detailed page go icon to follow link

PRKX (protein kinase X-linked) Show summary » More detailed page go icon to follow link

PRKY (protein kinase Y-linked (pseudogene)) Show summary » More detailed page go icon to follow link

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References

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How to cite this family page

Database page citation:

Protein kinase A (PKA) family. Accessed on 06/10/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=284.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.