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Immunoglobulin-like family of IL-1 receptors C
Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Overview
The immunoglobulin-like family of IL-1 receptors are heterodimeric receptors made up of a cognate receptor subunit and an IL-1 receptor accessory protein, IL1RAP (Q9NPH3, also known as C3orf13, IL-1RAcP, IL1R3). They are characterised by extracellular immunoglobulin-like domains and an intracellular Toll/Interleukin-1R (TIR) domain.
Receptors
Complexes
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Interleukin-1 receptor, type I
C
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Interleukin-33 receptor
C
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Interleukin-36 receptor
C
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Interleukin-1 receptor, type II
C
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Interleukin-18 receptor
C
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Receptors and Subunits
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Interleukin 1 receptor, type I
C
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Interleukin 1 receptor, type II
C
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Interleukin-1 receptor-like 1
C
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Interleukin-1 receptor-like 2
C
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Interleukin-18 receptor 1
C
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single Ig and TIR domain containing / IL-1R8
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Accessory Proteins
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IL-1 receptor accessory protein
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IL-18 receptor accessory protein
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Further reading
How to cite this family page
Database page citation:
Immunoglobulin-like family of IL-1 receptors. Accessed on 01/07/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=312.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors. Br J Pharmacol. 180 Suppl 2:S241-288.
