Immunoglobulin-like family of IL-1 receptors | Catalytic receptors

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Immunoglobulin-like family of IL-1 receptors

Immunoglobulin-like family of IL-1 receptors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The immunoglobulin-like family of IL-1 receptors are heterodimeric receptors made up of a cognate receptor subunit and an IL-1 receptor accessory protein, IL1RAP (Q9NPH3, also known as C3orf13, IL-1RAcP, IL1R3). They are characterised by extracellular immunoglobulin-like domains and an intracellular Toll/Interleukin-1R (TIR) domain.

Receptors

Complexes

Interleukin-1 receptor, type I C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin-33 receptor C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin-36 receptor C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin-1 receptor, type II C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin-18 receptor C Show summary »« Hide summary More detailed page go icon to follow link

Receptors and Subunits

Interleukin 1 receptor, type I C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	1734
Nomenclature	Interleukin 1 receptor, type I
Previous and unofficial names	CD121A \| IL1RA \| CD121 antigen-like family member A \| IL-1R-alpha \| interleukin 1 beta receptor type 1 short transmembrane form \| interleukin 1 beta receptor type 1 soluble form \| interleukin 1 bete receptor type 1 long transmembrane form \| interleukin-1 receptor alpha \| interleukin 1 receptor
Complexes	Interleukin-1 receptor, type I
Genes	IL1R1 (Hs), Il1r1 (Mm), Il1r1 (Rn)
Ensembl ID	ENSG00000115594 (Hs), ENSMUSG00000026072 (Mm), ENSRNOG00000014504 (Rn)
UniProtKB AC	P14778 (Hs), P13504 (Mm), Q02955 (Rn)

Interleukin 1 receptor, type II C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin-1 receptor-like 1 C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin-1 receptor-like 2 C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin-18 receptor 1 C Show summary »« Hide summary More detailed page go icon to follow link

single Ig and TIR domain containing / IL-1R8 Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2969
Nomenclature	single Ig and TIR domain containing
Systematic nomenclature	IL-1R8
Previous and unofficial names	single immunoglobulin and toll-interleukin 1 receptor (TIR) domain \| single immunoglobulin domain IL1R1 related \| TIR8
Genes	SIGIRR (Hs), Sigirr (Mm), Sigirr (Rn)
Ensembl ID	ENSG00000185187 (Hs), ENSMUSG00000025494 (Mm), ENSRNOG00000015593 (Rn)
UniProtKB AC	Q6IA17 (Hs), Q9JLZ8 (Mm), Q4V892 (Rn)

Accessory Proteins

IL-1 receptor accessory protein Show summary »« Hide summary More detailed page go icon to follow link

IL-18 receptor accessory protein Show summary »« Hide summary More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

Immunoglobulin-like family of IL-1 receptors. Accessed on 08/06/2023. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=312.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Catalytic receptors. Br J Pharmacol. 178 Suppl 1:S264-S312.