Immunoglobulin-like family of IL-1 receptors | Catalytic receptors

Home
Targets
Catalytic receptors
Cytokine receptor family
Immunoglobulin-like family of IL-1 receptors

Immunoglobulin-like family of IL-1 receptors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Show »« Hide

The immunoglobulin-like family of IL-1 receptors are heterodimeric receptors made up of a cognate receptor subunit and an IL-1 receptor accessory protein, IL1RAP (Q9NPH3, also known as C3orf13, IL-1RAcP, IL1R3). They are characterised by extracellular immunoglobulin-like domains and an intracellular Toll/Interleukin-1R (TIR) domain.

Receptors

Complexes

Interleukin-1 receptor, type I C Show summary »« Hide summary More detailed page

Interleukin-33 receptor C Show summary »« Hide summary More detailed page

Interleukin-36 receptor C Show summary »« Hide summary More detailed page

Interleukin-1 receptor, type II C Show summary »« Hide summary More detailed page

Interleukin-18 receptor C Show summary »« Hide summary More detailed page

Receptors and Subunits

Interleukin 1 receptor, type I C Show summary »« Hide summary More detailed page

Target Id	1734
Nomenclature	Interleukin 1 receptor, type I
Previous and unofficial names	CD121A \| IL1RA \| CD121 antigen-like family member A \| IL-1R-alpha \| interleukin 1 beta receptor type 1 short transmembrane form \| interleukin 1 beta receptor type 1 soluble form \| interleukin 1 bete receptor type 1 long transmembrane form \| interleukin-1 receptor alpha \| interleukin 1 receptor
Complexes	Interleukin-1 receptor, type I
Genes	IL1R1 (Hs), Il1r1 (Mm), Il1r1 (Rn)
Ensembl ID	ENSG00000115594 (Hs), ENSMUSG00000026072 (Mm), ENSRNOG00000014504 (Rn)
UniProtKB AC	P14778 (Hs), P13504 (Mm), Q02955 (Rn)

Interleukin 1 receptor, type II C Show summary »« Hide summary More detailed page

Interleukin-1 receptor-like 1 C Show summary »« Hide summary More detailed page

Interleukin-1 receptor-like 2 C Show summary »« Hide summary More detailed page

Interleukin-18 receptor 1 C Show summary »« Hide summary More detailed page

single Ig and TIR domain containing / IL-1R8 Show summary »« Hide summary More detailed page

Target Id	2969
Nomenclature	single Ig and TIR domain containing
Systematic nomenclature	IL-1R8
Previous and unofficial names	single immunoglobulin and toll-interleukin 1 receptor (TIR) domain \| single immunoglobulin domain IL1R1 related \| TIR8
Genes	SIGIRR (Hs), Sigirr (Mm), Sigirr (Rn)
Ensembl ID	ENSG00000185187 (Hs), ENSMUSG00000025494 (Mm), ENSRNOG00000015593 (Rn)
UniProtKB AC	Q6IA17 (Hs), Q9JLZ8 (Mm), Q4V892 (Rn)

Accessory Proteins

IL-1 receptor accessory protein Show summary »« Hide summary More detailed page

IL-18 receptor accessory protein Show summary »« Hide summary More detailed page

References

Show »« Hide

How to cite this family page

Database page citation:

Immunoglobulin-like family of IL-1 receptors. Accessed on 16/07/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=312.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Catalytic receptors. Br J Pharmacol. 174 Suppl 1: S225-S271.