The immunoglobulin-like family of IL-1 receptors are heterodimeric receptors made up of a cognate receptor subunit and an IL-1 receptor accessory protein, IL1RAP (Q9NPH3, also known as C3orf13, IL-1RAcP, IL1R3). They are characterised by extracellular immunoglobulin-like domains and an intracellular Toll/Interleukin-1R (TIR) domain.

* Key recommended reading is highlighted with an asterisk

* Afonina IS, Müller C, Martin SJ, Beyaert R. (2015) Proteolytic Processing of Interleukin-1 Family Cytokines: Variations on a Common Theme. Immunity, 42 (6): 991-1004. [PMID:26084020]

* Mantovani A, Dinarello CA, Molgora M, Garlanda C. (2019) Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity. Immunity, 50 (4): 778-795. DOI: 10.1016/j.immuni.2019.03.012 [PMID:30995499]

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