Top ▲

Receptor tyrosine phosphatase (RTP) family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Click here for help

« Hide

Receptor tyrosine phosphatases (RTP) are cell-surface proteins with a single TM region and intracellular phosphotyrosine phosphatase activity. Many family members exhibit constitutive activity in heterologous expression, dephosphorylating intracellular targets such as Src tyrosine kinase (SRC) to activate signalling cascades. Family members bind components of the extracellular matrix or cell-surface proteins indicating a role in intercellular communication.

Receptors

1858
Click here for help

RTP Type A C Show summary »

RTP Type B C Show summary » More detailed page go icon to follow link

RTP Type C C Show summary » More detailed page go icon to follow link

RTP Type D C Show summary » More detailed page go icon to follow link

RTP Type E C Show summary »

RTP Type F C Show summary » More detailed page go icon to follow link

RTP Type G C Show summary »

RTP Type H C Show summary »

RTP Type J C Show summary »


Target Id 1858
Nomenclature RTP Type J
Previous and unofficial names CD148 | density-enhanced phosphatase 1 | DEP1 | SCC1 | susceptibility to colon cancer 1 homologue | protein tyrosine phosphatase receptor type J | Byp | HPTPeta | protein tyrosine phosphatase | protein tyrosine phosphatase, receptor type J
Genes PTPRJ (Hs), Ptprj (Mm), Ptprj (Rn)
Ensembl ID ENSG00000149177 (Hs), ENSMUSG00000025314 (Mm), ENSRNOG00000034025 (Rn)
UniProtKB AC Q12913 (Hs), Q64455 (Mm)

RTP Type K C Show summary »

RTP Type M C Show summary »

RTP Type N C Show summary »

RTP Type N2 C Show summary »

RTP Type O C Show summary »

RTP Type Q C Show summary »

RTP Type R C Show summary »

RTP Type S C Show summary »

RTP Type T C Show summary »

RTP Type U C Show summary »

RTP Type Z1 C Show summary »

Further reading

Click here for help

Show »

References

Click here for help

Show »

How to cite this family page

Database page citation:

Receptor tyrosine phosphatase (RTP) family. Accessed on 05/08/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=333.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Catalytic receptors. Br J Pharmacol. 176 Suppl 1: S247-S296.