MAPKAPK subfamily

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Targets
Enzymes
Kinases (EC 2.7.x.x)
CAMK: Calcium/calmodulin-dependent protein kinases
MAPK-Activated Protein Kinase (MAPKAPK) family
MAPKAPK subfamily

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

MAPKAPK2 (MAPK activated protein kinase 2) Show summary »« Hide summary More detailed page go icon to follow link

MAPKAPK3 (MAPK activated protein kinase 3) Show summary »« Hide summary More detailed page go icon to follow link

MAPKAPK5 (MAPK activated protein kinase 5) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2096

Nomenclature

MAPK activated protein kinase 5

Common abbreviation

MAPKAPK5

Previous and unofficial names

MAPKAP kinase 5 | mitogen-activated protein kinase-activated protein kinase 5 | PRAK

Genes

MAPKAPK5 (Hs), Mapkapk5 (Mm), Mapkapk5 (Rn)

Ensembl ID

ENSG00000089022 (Hs), ENSMUSG00000029454 (Mm), ENSRNOG00000001345 (Rn)

UniProtKB AC

Q8IW41 (Hs), O54992 (Mm)

EC number

2.7.11.1

References

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1. Anderson DR, Meyers MJ, Vernier WF, Mahoney MW, Kurumbail RG, Caspers N, Poda GI, Schindler JF, Reitz DB, Mourey RJ. (2007) Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). J Med Chem, 50 (11): 2647-54. [PMID:17480064]

2. Lovering F, Kirincich S, Wang W, Combs K, Resnick L, Sabalski JE, Butera J, Liu J, Parris K, Telliez JB. (2009) Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Bioorg Med Chem, 17 (9): 3342-51. [PMID:19364658]

3. Mourey RJ, Burnette BL, Brustkern SJ, Daniels JS, Hirsch JL, Hood WF, Meyers MJ, Mnich SJ, Pierce BS, Saabye MJ et al.. (2010) A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor alpha production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation. J Pharmacol Exp Ther, 333 (3): 797-807. [PMID:20237073]

4. Schlapbach A, Feifel R, Hawtin S, Heng R, Koch G, Moebitz H, Revesz L, Scheufler C, Velcicky J, Waelchli R et al.. (2008) Pyrrolo-pyrimidones: a novel class of MK2 inhibitors with potent cellular activity. Bioorg Med Chem Lett, 18 (23): 6142-6. [PMID:18945615]

How to cite this family page

Database page citation:

MAPKAPK subfamily. Accessed on 06/10/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=512.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.