SMG1 subfamily

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Kinases (EC 2.7.x.x)
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Phosphatidyl inositol 3' kinase-related kinases (PIKK) family
SMG1 subfamily

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

SMG1 (SMG1 nonsense mediated mRNA decay associated PI3K related kinase) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2201

Nomenclature

SMG1 nonsense mediated mRNA decay associated PI3K related kinase

Common abbreviation

SMG1

Previous and unofficial names

ATX | LIP | SMG1 phosphatidylinositol 3-kinase-related kinase | SMG1, nonsense mediated mRNA decay associated PI3K related kinase | SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) | SMG1 | SMG1 homolog

Genes

SMG1 (Hs), Smg1 (Mm), Smg1 (Rn)

Ensembl ID

ENSG00000157106 (Hs), ENSMUSG00000030655 (Mm), ENSRNOG00000047386 (Rn)

UniProtKB AC

Q96Q15 (Hs), Q8BKX6 (Mm)

EC number

2.7.11.1

Selective inhibitors

compound 11j [PMID: 23021994] pIC₅₀ 10.0 [3]

Comment

SMG1 plays a critical role in nonsense-mediated RNA decay (NMD), which ensures integrity of translated proteins [1-2,4-5].

References

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1. Abraham RT. (2004) The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways. DNA Repair (Amst.), 3 (8-9): 919-25. [PMID:15279777]

2. Denning G, Jamieson L, Maquat LE, Thompson EA, Fields AP. (2001) Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein. J Biol Chem, 276 (25): 22709-14. [PMID:11331269]

3. Gopalsamy A, Bennett EM, Shi M, Zhang WG, Bard J, Yu K. (2012) Identification of pyrimidine derivatives as hSMG-1 inhibitors. Bioorg Med Chem Lett, 22 (21): 6636-41. [PMID:23021994]

4. Pulak R, Anderson P. (1993) mRNA surveillance by the Caenorhabditis elegans smg genes. Genes Dev, 7 (10): 1885-97. [PMID:8104846]

5. Yamashita A, Kashima I, Ohno S. (2005) The role of SMG-1 in nonsense-mediated mRNA decay. Biochim Biophys Acta, 1754 (1-2): 305-15. [PMID:16289965]

How to cite this family page

Database page citation:

SMG1 subfamily. Accessed on 27/09/2023. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=530.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.