p70 subfamily

From August 18th 2026, GtoPdb will require users to register to use the website. Please see our blog post for more information.

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

p70S6K (ribosomal protein S6 kinase B1) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1525

Nomenclature

ribosomal protein S6 kinase B1

Common abbreviation

p70S6K

Previous and unofficial names

Genes

RPS6KB1 (Hs), Rps6kb1 (Mm), Rps6kb1 (Rn)

Ensembl ID

ENSG00000108443 (Hs), ENSMUSG00000020516 (Mm), ENSRNOG00000003919 (Rn)

UniProtKB AC

P23443 (Hs), Q8BSK8 (Mm), P67999 (Rn)

EC number

2.7.11.1

Comment

Ribosomal S6 kinases 70 kDa, also known as p70^rsk, are activated by MAP kinase-mediated phosphorylation

p70S6Kβ (ribosomal protein S6 kinase B2) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1526

Nomenclature

ribosomal protein S6 kinase B2

Common abbreviation

p70S6Kβ

Previous and unofficial names

S6Kβ2 | ribosomal protein S6 kinase, 70kD, polypeptide 2 | ribosomal protein S6 kinase beta-2 | S6K2 | KLS | STK14B | ribosomal protein S6 kinase

Genes

RPS6KB2 (Hs), Rps6kb2 (Mm), Rps6kb2 (Rn)

Ensembl ID

ENSG00000175634 (Hs), ENSMUSG00000024830 (Mm), ENSRNOG00000021689 (Rn)

UniProtKB AC

Q9UBS0 (Hs), Q9Z1M4 (Mm)

EC number

2.7.11.1

Comment

Ribosomal S6 kinases 70 kDa, also known as p70^rsk, are activated by MAP kinase-mediated phosphorylation

How to cite this family page

Database page citation:

p70 subfamily. Accessed on 15/08/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=540.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Enzymes. Br J Pharmacol. 182: S307-S403.