CAMK2 family

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Enzymes
Kinases (EC 2.7.x.x)
CAMK: Calcium/calmodulin-dependent protein kinases
CAMK2 family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

CaMKII (Calmodulin-dependent kinase II) Show summary »« Hide summary More detailed page

Target Id

1554

Nomenclature

Calmodulin-dependent kinase II

Common abbreviation

CaMKII

EC number

2.7.11.17

Endogenous activators

calmodulin (CALM2, CALM3, CALM1, P62158)

Selective inhibitors

K-252a [1]

Comment

Camodulin-dependent kinase II is a homo- or heterotromultimeric holoenzyme made up of 8 to 12 subunit chains.

STO609 is an inhibitor of calmodulin kinase kinase [4], an upstream activator of calmodulin-dependent kinase.

CaMK2α (calcium/calmodulin-dependent protein kinase II alpha subunit) Show summary »« Hide summary More detailed page

Target Id

1555

Nomenclature

calcium/calmodulin-dependent protein kinase II alpha subunit

Common abbreviation

CaMK2α

Previous and unofficial names

Genes

CAMK2A (Hs), Camk2a (Mm), Camk2a (Rn)

Ensembl ID

ENSG00000070808 (Hs), ENSMUSG00000024617 (Mm), ENSRNOG00000018712 (Rn)

UniProtKB AC

Q9UQM7 (Hs), P11798 (Mm), P11275 (Rn)

EC number

2.7.11.17

CaMK2β (calcium/calmodulin-dependent protein kinase II beta subunit) Show summary »« Hide summary More detailed page

Target Id

1556

Nomenclature

calcium/calmodulin-dependent protein kinase II beta subunit

Common abbreviation

CaMK2β

Previous and unofficial names

Genes

CAMK2B (Hs), Camk2b (Mm), Camk2b (Rn)

Ensembl ID

ENSG00000058404 (Hs), ENSMUSG00000057897 (Mm), ENSRNOG00000004005 (Rn)

UniProtKB AC

Q13554 (Hs), P28652 (Mm), P08413 (Rn)

EC number

2.7.11.17

CaMK2γ (calcium/calmodulin-dependent protein kinase II gamma subunit) Show summary »« Hide summary More detailed page

CaMK2δ (calcium/calmodulin-dependent protein kinase II delta subunit) Show summary »« Hide summary More detailed page

References

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1. Hashimoto Y, Nakayama T, Teramoto T, Kato H, Watanabe T, Kinoshita M, Tsukamoto K, Tokunaga K, Kurokawa K, Nakanishi S. (1991) Potent and preferential inhibition of Ca2+/calmodulin-dependent protein kinase II by K252a and its derivative, KT5926. Biochem. Biophys. Res. Commun., 181 (1): 423-9. [PMID:1659814]

2. Lu Q, Chen Z, Perumattam J, Wang DX, Liang W, Xu YJ, Do S, Bonaga L, Higaki J, Dong H et al.. (2008) Aryl-indolyl maleimides as inhibitors of CaMKIIdelta. Part 3: Importance of the indole orientation. Bioorg. Med. Chem. Lett., 18 (7): 2399-403. [PMID:18337095]

3. Mavunkel B, Xu YJ, Goyal B, Lim D, Lu Q, Chen Z, Wang DX, Higaki J, Chakraborty I, Liclican A et al.. (2008) Pyrimidine-based inhibitors of CaMKIIdelta. Bioorg. Med. Chem. Lett., 18 (7): 2404-8. [PMID:18334293]

4. Tokumitsu H, Inuzuka H, Ishikawa Y, Ikeda M, Saji I, Kobayashi R. (2002) STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase. J. Biol. Chem., 277 (18): 15813-8. [PMID:11867640]

How to cite this family page

Database page citation:

CAMK2 family. Accessed on 22/10/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=562.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.