Casein kinase 1 (CK1) family

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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

CK1-A (casein kinase 1 alpha 1) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1995

Nomenclature

casein kinase 1 alpha 1

Common abbreviation

CK1-A

Previous and unofficial names

Genes

CSNK1A1 (Hs), Csnk1a1 (Mm), Csnk1a1 (Rn)

Ensembl ID

ENSG00000113712 (Hs), ENSMUSG00000024576 (Mm), ENSRNOG00000072163 (Rn)

UniProtKB AC

P48729 (Hs), Q8BK63 (Mm), P97633 (Rn)

EC number

2.7.11.1

Ligands

ABT-002 (Binding) (Degrader: DC₅₀ >1000 nM)) [2]

CK1-A2 (casein kinase 1 alpha 1 like) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1996

Nomenclature

casein kinase 1 alpha 1 like

Common abbreviation

CK1-A2

Previous and unofficial names

CKI-alpha-like | casein kinase 1, alpha 1-like

Genes

CSNK1A1L (Hs)

Ensembl ID

ENSG00000180138 (Hs)

UniProtKB AC

Q8N752 (Hs)

EC number

2.7.11.1

CK1-G1 (casein kinase 1 gamma 1) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1999

Nomenclature

casein kinase 1 gamma 1

Common abbreviation

CK1-G1

Previous and unofficial names

CKI-gamma 1 | casein kinase 1

Genes

CSNK1G1 (Hs), Csnk1g1 (Mm), Csnk1g1 (Rn)

Ensembl ID

ENSG00000169118 (Hs), ENSMUSG00000032384 (Mm), ENSRNOG00000016620 (Rn)

UniProtKB AC

Q9HCP0 (Hs), Q8BTH8 (Mm), Q62761 (Rn)

EC number

2.7.11.1

Inhibitors

SGC-CK1γ-1 pIC₅₀ 6.7 [1]

Comment

CK1-G1 and -G3 phosphorylate and enhance the kinase activity of receptor-interacting serine/threonine kinase 3 (RIPK3) which induces necroptosis [4].

CK1-G2 (casein kinase 1 gamma 2) Show summary »« Hide summary More detailed page go icon to follow link

CK1-G3 (casein kinase 1 gamma 3) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2001

Nomenclature

casein kinase 1 gamma 3

Common abbreviation

CK1-G3

Previous and unofficial names

CKI-gamma 3 | casein kinase 1

Genes

CSNK1G3 (Hs), Csnk1g3 (Mm), Csnk1g3 (Rn)

Ensembl ID

ENSG00000151292 (Hs), ENSMUSG00000073563 (Mm), ENSRNOG00000016677 (Rn)

UniProtKB AC

Q9Y6M4 (Hs), Q8C4X2 (Mm), Q62763 (Rn)

EC number

2.7.11.1

Inhibitors

SGC-CK1γ-1 pIC₅₀ 6.6 [1]

Comment

CK1-G1 and -G3 phosphorylate and enhance the kinase activity of receptor-interacting serine/threonine kinase 3 (RIPK3) which induces necroptosis [4].

CK1-D (casein kinase 1 delta) Show summary »« Hide summary More detailed page go icon to follow link

CK1-E (casein kinase 1 epsilon) Show summary »« Hide summary More detailed page go icon to follow link

References

Show »« Hide

1. Capener JL, Kramer TW, Bashore FM, Flory E, Li F, Strang BL, Axtman AD. (2026) Development of a Chemical Probe to Enable Characterization of the Casein Kinase 1γ Subfamily. J Med Chem, 69 (3): 2666-2684. [PMID:41587072]

2. Glaza P, Pluta R, Odrzywół KE, Klejnot M, Wieczorek M, Cottens S, Coppen D, Dobrzański P, Drmota T, Lis-Grześniak J et al.. (2025) Targeted degradation of GSPT1 and NEK7 by a molecular glue prodrug for treatment of HCC. Commun Chem, 8 (1): 247. [PMID:40813917]

3. Huang H, Acquaviva L, Berry V, Bregman H, Chakka N, O'Connor A, DiMauro EF, Dovey J, Epstein O, Grubinska B et al.. (2012) Structure-Based Design of Potent and Selective CK1γ Inhibitors. ACS Med Chem Lett, 3 (12): 1059-64. [PMID:24900428]

4. Lee SY, Kim H, Li CM, Kang J, Najafov A, Jung M, Kang S, Wang S, Yuan J, Jung YK. (2019) Casein kinase-1γ1 and 3 stimulate tumor necrosis factor-induced necroptosis through RIPK3. Cell Death Dis, 10 (12): 923. [PMID:31801942]

5. Li D, Ai Y, Guo J, Dong B, Li L, Cai G, Chen S, Xu D, Wang F, Wang X. (2020) Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-interacting kinase 3. Elife, 9. [PMID:33206046]

6. Walton KM, Fisher K, Rubitski D, Marconi M, Meng QJ, Sládek M, Adams J, Bass M, Chandrasekaran R, Butler T et al.. (2009) Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period. J Pharmacol Exp Ther, 330 (2): 430-9. [PMID:19458106]

How to cite this family page

Database page citation:

Casein kinase 1 (CK1) family. Accessed on 09/04/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=564.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Enzymes. Br J Pharmacol. 182: S307-S403.