Leucine-rich repeat kinase (LRRK) family

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Kinases (EC 2.7.x.x)
TKL: Tyrosine kinase-like
Leucine-rich repeat kinase (LRRK) family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

LRRK1 (leucine rich repeat kinase 1) Show summary »« Hide summary More detailed page

LRRK2 (leucine rich repeat kinase 2) Show summary »« Hide summary More detailed page

Target Id

2059

Nomenclature

leucine rich repeat kinase 2

Common abbreviation

LRRK2

Previous and unofficial names

Park8 | Parkinson disease (autosomal dominant) 8 | ROCO2 | RIPK7 | leucine-rich repeat kinase 2

Genes

LRRK2 (Hs), Lrrk2 (Mm), Lrrk2 (Rn)

Ensembl ID

ENSG00000188906 (Hs), ENSMUSG00000036273 (Mm), ENSRNOG00000004048 (Rn)

UniProtKB AC

Q5S007 (Hs), Q5S006 (Mm)

EC number

2.7.11.1

Inhibitors

GNE-7915 (Binding) pK_i 9.0 [1]

GNE-9605 pIC₅₀ 7.7 [1]

Selective inhibitors

PF-06447475 pIC₅₀ 8.5 [2]

GNE-7915 pIC₅₀ 8.1 [1]

References

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How to cite this family page

Database page citation:

Leucine-rich repeat kinase (LRRK) family. Accessed on 24/10/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=582.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.