MAST family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

MAST1 (Microtubule associated serine/threonine kinase 1) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1510

Nomenclature

Microtubule associated serine/threonine kinase 1

Common abbreviation

MAST1

Previous and unofficial names

syntrophin associated serine/threonine kinase | SAST170 | SAST

Genes

MAST1 (Hs), Mast1 (Mm), MAST1 (Rn)

Ensembl ID

ENSG00000105613 (Hs), ENSMUSG00000053693 (Mm), ENSRNOG00000003469 (Rn)

UniProtKB AC

Q9Y2H9 (Hs), Q9R1L5 (Mm), Q810W7 (Rn)

EC number

2.7.11.1

Comment

Members of the microtubule-associated serine/threonine kinase family appear to have a role in platelet production [1] and inflammatory bowel disease [2].

MAST2 (Microtubule associated serine/threonine kinase 2) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1511

Nomenclature

Microtubule associated serine/threonine kinase 2

Common abbreviation

MAST2

Previous and unofficial names

Mtssk | MAST205

Genes

MAST2 (Hs), Mast2 (Mm), Mast2 (Rn)

Ensembl ID

ENSG00000086015 (Hs), ENSMUSG00000003810 (Mm), ENSRNOG00000058476 (Rn)

UniProtKB AC

Q6P0Q8 (Hs), Q60592 (Mm)

EC number

2.7.11.1

Comment

Members of the microtubule-associated serine/threonine kinase family appear to have a role in platelet production [1] and inflammatory bowel disease [2]

MAST3 (Microtubule associated serine/threonine kinase 3) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1512

Nomenclature

Microtubule associated serine/threonine kinase 3

Common abbreviation

MAST3

Genes

MAST3 (Hs), Mast3 (Mm), Mast3 (Rn)

Ensembl ID

ENSG00000099308 (Hs), ENSMUSG00000031833 (Mm), ENSRNOG00000022753 (Rn)

UniProtKB AC

O60307 (Hs), Q3U214 (Mm)

EC number

2.7.11.1

Inhibitors

compound 35 [PMID: 23916259] pIC₅₀ 6.6 [3]

Comment

Members of the microtubule-associated serine/threonine kinase family appear to have a role in platelet production [1] and inflammatory bowel disease [2]

MAST4 (Microtubule associated serine/threonine kinase 4) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1513

Nomenclature

Microtubule associated serine/threonine kinase 4

Common abbreviation

MAST4

Genes

MAST4 (Hs), Mast4 (Mm), Mast4 (Rn)

Ensembl ID

ENSG00000069020 (Hs), ENSMUSG00000034751 (Mm), ENSRNOG00000027002 (Rn)

UniProtKB AC

O15021 (Hs), Q811L6 (Mm)

EC number

2.7.11.1

Comment

Members of the microtubule-associated serine/threonine kinase family appear to have a role in platelet production [1] and inflammatory bowel disease [2]

MASTL (Microtubule associated serine/threonine kinase-like) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1514

Nomenclature

Microtubule associated serine/threonine kinase-like

Common abbreviation

MASTL

Previous and unofficial names

GWL | GWLlGwl | Serine/threonine-protein kinase greatwall | THC2 | microtubule associated serine/threonine kinase-like

Genes

MASTL (Hs), Mastl (Mm), Mastl (Rn)

Ensembl ID

ENSG00000120539 (Hs), ENSMUSG00000026779 (Mm), ENSRNOG00000054474 (Rn)

UniProtKB AC

Q96GX5 (Hs), Q8C0P0 (Mm)

EC number

2.7.11.1

Comment

Members of the microtubule-associated serine/threonine kinase family appear to have a role in platelet production [1] and inflammatory bowel disease [2]

References

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1. Johnson HJ, Gandhi MJ, Shafizadeh E, Langer NB, Pierce EL, Paw BH, Gilligan DM, Drachman JG. (2009) In vivo inactivation of MASTL kinase results in thrombocytopenia. Exp Hematol, 37 (8): 901-8. [PMID:19460416]

2. Labbé C, Goyette P, Lefebvre C, Stevens C, Green T, Tello-Ruiz MK, Cao Z, Landry AL, Stempak J, Annese V et al.. (2008) MAST3: a novel IBD risk factor that modulates TLR4 signaling. Genes Immun, 9 (7): 602-12. [PMID:18650832]

3. Li B, Cociorva OM, Nomanbhoy T, Weissig H, Li Q, Nakamura K, Liyanage M, Zhang MC, Shih AY, Aban A et al.. (2013) Hit-to-lead optimization and kinase selectivity of imidazo[1,2-a]quinoxalin-4-amine derived JNK1 inhibitors. Bioorg Med Chem Lett, 23 (18): 5217-22. [PMID:23916259]

How to cite this family page

Database page citation:

MAST family. Accessed on 08/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=583.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.