Myosin Light Chain Kinase (MLCK) family

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Enzymes
Kinases (EC 2.7.x.x)
CAMK: Calcium/calmodulin-dependent protein kinases
Myosin Light Chain Kinase (MLCK) family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

smMLCK (myosin light chain kinase) Show summary »« Hide summary More detailed page go icon to follow link

skMLCK (myosin light chain kinase 2) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1553

Nomenclature

myosin light chain kinase 2

Common abbreviation

skMLCK

Previous and unofficial names

myosin light chain kinase 2, skeletal/cardiac muscle | MLCK2 (skeletal muscle isoform) | KMLC | myosin, light polypeptide kinase 2, skeletal muscle | myosin

Genes

MYLK2 (Hs), Mylk2 (Mm), Mylk2 (Rn)

Ensembl ID

ENSG00000101306 (Hs), ENSMUSG00000027470 (Mm), ENSRNOG00000008235 (Rn)

UniProtKB AC

Q9H1R3 (Hs), Q8VCR8 (Mm), P20689 (Rn)

EC number

2.7.11.18

Endogenous activators

calmodulin (CALM2, CALM3, CALM1, P62158) [1]

caMLCK (myosin light chain kinase 3) Show summary »« Hide summary More detailed page go icon to follow link

Sgk085 (myosin light chain kinase family member 4) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2111

Nomenclature

myosin light chain kinase family member 4

Common abbreviation

Sgk085

Previous and unofficial names

Sugen kinase 85 | myosin light chain kinase family, member 4 | myosin light chain kinase family

Genes

MYLK4 (Hs), Mylk4 (Mm)

Ensembl ID

ENSG00000145949 (Hs), ENSMUSG00000044951 (Mm)

UniProtKB AC

Q86YV6 (Hs), Q5SUV5 (Mm)

EC number

2.7.11.1

titin Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2265

Nomenclature

titin

Previous and unofficial names

Genes

TTN (Hs), Ttn (Mm), Ttn (Rn)

Ensembl ID

ENSG00000155657 (Hs), ENSMUSG00000051747 (Mm), ENSRNOG00000069271 (Rn)

UniProtKB AC

Q8WZ42 (Hs), A2ASS6 (Mm)

EC number

2.7.11.1

References

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How to cite this family page

Database page citation:

Myosin Light Chain Kinase (MLCK) family. Accessed on 14/08/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=585.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Enzymes. Br J Pharmacol. 182: S307-S403.