SGK family

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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

SGK1 (serum/glucocorticoid regulated kinase 1) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1534

Nomenclature

serum/glucocorticoid regulated kinase 1

Common abbreviation

SGK1

Previous and unofficial names

serine/threonine-protein kinase Sgk1

Genes

SGK1 (Hs), Sgk1 (Mm), Sgk1 (Rn)

Ensembl ID

ENSG00000118515 (Hs), ENSMUSG00000019970 (Mm), ENSRNOG00000011815 (Rn)

UniProtKB AC

O00141 (Hs), Q9WVC6 (Mm), Q06226 (Rn)

EC number

2.7.11.1

Selective inhibitors

GSK650394 pIC₅₀ 7.2 [2]

Comment

Serum- and glucocorticoid-inducible kinases are regulated at the transcriptional level by serum and glucocorticoids. SGK1 has been reported to be phosphorylated and activated by mouse TORC2 (Q3U182) [1].

SGK2 (serum/glucocorticoid regulated kinase 2) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1535

Nomenclature

serum/glucocorticoid regulated kinase 2

Common abbreviation

SGK2

Previous and unofficial names

serine/threonine-protein kinase Sgk2 | SGK2 | SGK2, serine/threonine kinase 2

Genes

SGK2 (Hs), Sgk2 (Mm), Sgk2 (Rn)

Ensembl ID

ENSG00000101049 (Hs), ENSMUSG00000017868 (Mm), ENSRNOG00000033573 (Rn)

UniProtKB AC

Q9HBY8 (Hs), Q9QZS5 (Mm), Q8R4U9 (Rn)

EC number

2.7.11.1

Selective inhibitors

GSK650394 pIC₅₀ 7.0 [2]

Comment

Serum- and glucocorticoid-inducible kinases are regulated at the transcriptional level by serum and glucocorticoids

SGK3 (serum/glucocorticoid regulated kinase family member 3) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1536

Nomenclature

serum/glucocorticoid regulated kinase family member 3

Common abbreviation

SGK3

Previous and unofficial names

Genes

SGK3 (Hs), Sgk3 (Mm), Sgk3 (Rn)

Ensembl ID

ENSG00000104205 (Hs), ENSMUSG00000025915 (Mm), ENSRNOG00000049052 (Rn)

UniProtKB AC

Q96BR1 (Hs), Q9ERE3 (Mm), Q8R4V0 (Rn)

EC number

2.7.11.1

Comment

Serum- and glucocorticoid-inducible kinases are regulated at the transcriptional level by serum and glucocorticoids

References

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How to cite this family page

Database page citation:

SGK family. Accessed on 16/08/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=616.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Enzymes. Br J Pharmacol. 182: S307-S403.