Syk family

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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

Syk (spleen associated tyrosine kinase) Show summary »« Hide summary More detailed page go icon to follow link

ZAP70 (zeta chain of T cell receptor associated protein kinase 70) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2285

Nomenclature

zeta chain of T cell receptor associated protein kinase 70

Common abbreviation

ZAP70

Previous and unofficial names

SRK | STD | syk-related protein tyrosine kinase | TZK | zeta chain of T cell receptor associated protein kinase 70kDa | zeta-chain (TCR) associated protein kinase 70 | zeta chain of T-cell receptor associated protein kinase 70

Genes

ZAP70 (Hs), Zap70 (Mm), Zap70 (Rn)

Ensembl ID

ENSG00000115085 (Hs), ENSMUSG00000026117 (Mm), ENSRNOG00000016995 (Rn)

UniProtKB AC

P43403 (Hs), P43404 (Mm)

EC number

2.7.10.2

References

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1. Braselmann S, Taylor V, Zhao H, Wang S, Sylvain C, Baluom M, Qu K, Herlaar E, Lau A, Young C et al.. (2006) R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J Pharmacol Exp Ther, 319 (3): 998-1008. [PMID:16946104]

2. Coffey G, DeGuzman F, Inagaki M, Pak Y, Delaney SM, Ives D, Betz A, Jia ZJ, Pandey A, Baker D et al.. (2012) Specific inhibition of spleen tyrosine kinase suppresses leukocyte immune function and inflammation in animal models of rheumatoid arthritis. J Pharmacol Exp Ther, 340 (2): 350-9. [PMID:22040680]

3. Currie KS, Kropf JE, Lee T, Blomgren P, Xu J, Zhao Z, Gallion S, Whitney JA, Maclin D, Lansdon EB et al.. (2014) Discovery of GS-9973, a selective and orally efficacious inhibitor of spleen tyrosine kinase. J Med Chem, 57 (9): 3856-73. [PMID:24779514]

4. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]

5. Xie HZ, Li LL, Ren JX, Zou J, Yang L, Wei YQ, Yang SY. (2009) Pharmacophore modeling study based on known spleen tyrosine kinase inhibitors together with virtual screening for identifying novel inhibitors. Bioorg Med Chem Lett, 19 (7): 1944-9. [PMID:19254842]

How to cite this family page

Database page citation:

Syk family. Accessed on 16/08/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=625.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Enzymes. Br J Pharmacol. 182: S307-S403.