Trio family

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Targets
Enzymes
Kinases (EC 2.7.x.x)
CAMK: Calcium/calmodulin-dependent protein kinases
Trio family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

Trad (kalirin RhoGEF kinase) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2050

Nomenclature

kalirin RhoGEF kinase

Common abbreviation

Trad

Previous and unofficial names

Genes

KALRN (Hs), Kalrn (Mm), Kalrn (Rn)

Ensembl ID

ENSG00000160145 (Hs), ENSMUSG00000061751 (Mm), ENSRNOG00000001706 (Rn)

UniProtKB AC

O60229 (Hs), A2CG49 (Mm), P97924 (Rn)

EC number

2.7.11.1

Obscn (obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2131

Nomenclature

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

Common abbreviation

Obscn

Previous and unofficial names

Obscurin-MLCK | Obscurin-myosin light chain kinase

Genes

OBSCN (Hs), Obscn (Mm), Obscn (Rn)

Ensembl ID

ENSG00000154358 (Hs), ENSMUSG00000061462 (Mm), ENSRNOG00000058068 (Rn)

UniProtKB AC

Q5VST9 (Hs), A2AAJ9 (Mm)

EC number

2.7.11.1

SPEG (striated muscle enriched protein kinase) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2203

Nomenclature

striated muscle enriched protein kinase

Common abbreviation

SPEG

Previous and unofficial names

aortic preferentially expressed gene 1 | APEG1 | BPEG | SPEG complex locus

Genes

SPEG (Hs), Speg (Mm), Speg (Rn)

Ensembl ID

ENSG00000072195 (Hs), ENSMUSG00000026207 (Mm), ENSRNOG00000019850 (Rn)

UniProtKB AC

Q15772 (Hs), Q62407 (Mm), Q63638 (Rn)

EC number

2.7.11.1

TRIO (trio Rho guanine nucleotide exchange factor) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2255

Nomenclature

trio Rho guanine nucleotide exchange factor

Common abbreviation

TRIO

Previous and unofficial names

Solo | triple functional domain (PTPRF interacting)

Genes

TRIO (Hs), Trio (Mm), Trio (Rn)

Ensembl ID

ENSG00000038382 (Hs), ENSMUSG00000022263 (Mm), ENSRNOG00000012148 (Rn)

UniProtKB AC

O75962 (Hs), Q0KL02 (Mm)

EC number

2.7.11.1

How to cite this family page

Database page citation:

Trio family. Accessed on 19/07/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=636.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.